Dr. Guo constructed an in vitro phi29 DNA packaging motor (the most powerful biomotor constructed to date) (PNAS, 1986); discovered the motor pRNA (Science, 1987) and elucidated the formation of hexameric pRNA (Molecular Cell, 1998). He demonstrated that RNA can be used as building blocks for bottom-up assemlby in nanotechnology, and for constructing nanoparticles to co-deliver multiple therapeutic molecules to specific cells. His lab has assembled a home-made State-of-the-Art dual viewing system that can easily detect single-fluorophores and for single molecule studies (EMBO J 2007). He has chaired or been the keynote speaker at numerous prestigious symposia and international conferences. He received the award of Pfizer Distinguished Faculty Award for Research Excellence in 1995, the Purdue Faculty Scholar in 1998, the Seed Award in 2004, 2005, 2007 and Lion Club Cancer Research Award in 2006. In 2005, he was selected by Foresight Nanotech Institute as a Finalist --one of the top five researchers in nanotechnology for a Feynman Prize.

Dr. Guo is an editor or editorial board member for six journals, including four in nanotechnology. His work has been reported hundreds of times on radio, TV, such as ABC, NBC, and WLFI, and other important web sites including NCI, NIH, NSF, MSNBC, and Science. Dr. Guo has been invited by NIST, NIH, NSF and National Council of Nanotechnology to participate in two prominent national nanotech initiatives. Currently he is the member of NIH steering committee for Nanomedicine Development Centers.