ORIGINAL PAPERS IN REFEREED SCIENTIFIC JOURNALS

Vemula SV, Amen O, Katz JM, Donis R, Sambhara S and Mittal SK.( 2013) Beta-defensin 2 enhances immunogenicity and protection of an adenovirus-based H5N1 influenza vaccine at an early time. Virus Res. 178:(2): 398-403.  PUBMED

Vemula SV, Pandey A, Singh N, Katz JM, Donis R, Sambhara S and Mittal SK.( 2013) Adenoviral vector expressing murine beta-defensin 2 enhances immunogenicity of an adenoviral vector based H5N1 influenza vaccine in aged mice. Virus Res. 177:55-61. PUBMED

Ahi YS, Vemula SV and Mittal SK. (2013) Adenoviral E2 IVa2 protein interacts with L4 33K protein and E2 DNA-Binding protein. J.Gen.Virol. 94:1325-34. PUBMED

Vemula SV, Ahi YS, Swaim AM, Katz JM, Donis R, Sambhara S and Mittal SK.( 2013) Broadly Protective Adenovirus-Based Multivalent Vaccines against Highly Pathogenic Avian Influenza Viruses for Pandemic Preparedness. PLoS.One. 8:(4): e62496-. PUBMED

Mittal S.K., HogenEsch H, Vemulapalli R, and Park K. (2013) Chapter:342. Vaccines, adjuvants, and delivery systems for infectious diseases.In: Encyclopedia of Pharmaceutical Science and Technology. edited by Swarbrick, J. Informa Healthcare. pp. 3727-3747.

Tandon M, Vemula SV, Sharma A, Ahi YS, Mittal S, Bangari DS, and Mittal SK. (2012) EphrinA1-EphA2 interaction-mediated apoptosis and FMS-like tryosine kinase 3 receptor ligand-induced immunotherapy inhibit tumor growth in a breast cancer mouse model. J Gene Med 14(2):77-89. PUBMED

Tandon M, Sharma A, Vemula SV, Bangari DS, and Mittal SK. (2012) Sequential administration of bovine and human adenovirus vectors to overcome vector immunity in an immunocompetent mouse model of breast cancer. Virus Res. 163(1):202-211. PUBMED

Pandey A, Singh N, Vemula SV, Couetil L, Katz J M, Donis R, Sambhara S, and Mittal S.K. (2012) Impact of preexisting adenovirus vector immunity on immunogenicity and protection conferred with an adenovirus-based H5N1 influenza vaccine. PLoS ONE 7(3):e33428-e33428. PUBMED

Harrach B, Benko M, Both GW, Brown M, Davison AJ, Echavarria M, Hess M, Jones MS, Kajon A, Lehmkuhl HD, Mautner V, Mittal SK, and Wadell G. (2011) The Double Stranded DNA Viruses: Adenoviridae. In: Virus Taxonomy: Ninth Report of the International Committee on Taxonomy of Viruses. Editors: King AMQ, Adams MJ, Carstens EB, Lefkowitz EJ. Academic Press: Elsevier. Waltham MA. pp.125-141.

Mittal SK, Swaim A, and Ahi YS. (2011) Adenoviral vectors: Potential and challenges as a gene delivery vehicle. In: Viral Gene Therapy. Editors: Xu K. InTech Open Access Book 91-128. LINK

Sharma A, Bangari DS, Vemula SV, and Mittal SK. (2011). Persistence and the state of bovine and porcine adenoviral vector genomes in human and nonhuman cell lines. Virus Res. 161(2):181-187. PUBMED

Ahi YS, Bangari DS and Mittal SK. (2011). Adenoviral vector immunity: its implications and circumvention strategies. Curr. Gene Ther. 11(4):307-320. PUBMED

Tandon M, Vemula S and Mittal SK. (2011). Emerging strategies for EphA2 receptor targeting for cancer therapeutics. Expert Opin Ther Targets. 15(1):31-51. PUBMED

Sharma A, Bangari DS, Tandon M, Pandey A, HogenEsch H and Mittal SK. (2010). Evaluation of innate immunity and vector toxicity following intravenous inoculation of bovine, porcine and human adenoviral vectors in a mouse model. Virus Res. 153:134–42. PUBMED

Vemula S and Mittal SK. (2010). Production of adenovirus vectors and their use as a delivery system for influenza vaccines. Expert Opin Biol Ther. 10(10):1469-87. PUBMED

Sharma A, Tandon M, Ahi Y, Bangari DS, Vemulapalli R and Mittal S. (2010). Evaluation of Cross-Reactive Humoral and Cell-Mediated Immune Responses among Human, Bovine and Porcine Adenoviruses. Gene Ther. 2010 May;17(5):634-42. PUBMED

Singh N, Pandey A, Sambhara S and Mittal SK. (2010). Avian influenza pandemic preparedness: developing prepandemic and pandemic vaccines against a moving target. Expert Reviews in Molecular Medicine.Apr 29;12:e14. PUBMED

Pandey A, Singh N, Sambhara S and Suresh K. Mittal. (2009). Egg-independent vaccine strategies for highly pathogenic H5N1 influenza viruses. Human Vaccine. 2010 6(2):178-188. PUBMED

Sharma A, Tandon M, Bangari DS and Mittal SK. (2009) Adenovirus vector-based strategies for cancer therapy. Current Drug Therapy. 4(2): 117-138. PUBMED

Sharma A, Li X, Bangari, DS and Mittal SK. (2009). Adenovirus receptors and their implications in gene delivery. Virus Res. 143(2):184-94. PUBMED

Li X, Bangari DS, Sharma A and Mittal SK. (2009) Bovine adenovrius serotype 3 utilizes sialic acid as a cellular receptor for virus entry. Virology. 392(2):162-168. PUBMED

Sharma A, Bangari DS, Tandon M, Pandey A, HogenEsch H and Mittal SK. (2009). Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology. 386(1):44-54. PUBMED

Bangari D, Miller M, Stevenson G, Thacker H, Sharma A, and Mittal SK. (2009). Cutaneous and Systemic Poxviral Disease in Red (Tamiasciurus hudsonicus) and Gray (Sciurus carolinensis) Squirrels. Vet Pathol. 46(4):667-72 PUBMED

Singh N, Pandey A, Jayashankar L and Mittal SK. (2008). Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus. Mol. Ther. 16(5):965-971 PUBMED

Hoelscher MA, Singh N, Garg S, Jayashankar L, Veguilla V, Pandey A, Matsuoka Y, Katz JM, Donis R, Mittal SK and Sambhara S. (2008). A broadly-protective pandemic influenza vaccine against clade 1 and clade 2 H5N1 viruses. J. Infect. Dis. 197(8):1185-8. PUBMED

Hoelscher MA, Jayashankar L, Garg S, Veguilla V, Lu X, Singh N, Katz JM, Mittal SK and Sambhara S. (2007). New pre-pandemic influenza vaccines: An egg- and adjuvant-independent human adenoviral vector strategy induces long lasting protective immune responses in mice. Clin. Pharmacol. Ther. 82:665-671. PUBMED

Mittal SK. Respiratory viruses of animals causing disease in humans - Keystone Symposium. IDrugs. 2007 10(3):156-8. PUBMED

Bangari DS, Mittal SK. 2006. Current strategies and future directions for eluding adenoviral vector immunity. Current Gene Therapy. 6:215-226. PUBMED

Hoelscher MA, Garg S, Bangari DS, et al. 2006. Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet. 367(9509):475-81. PUBMED

Abraham S, Knapp DW, Cheng L, Snyder PW, Mittal SK, Bangari DS, Kinch M, Wu L, Dhariwal J, and Mohammed SI. 2006. Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder. Clin Cancer Res. 12(2):353-60. PUBMED

Gil L, van Olphen A , Mittal SK and Donis RO. 2006. Modulation of PKR activity in cells infected by bovine viral diarrhea virus. Virus Res. 116(1-2):69-77. PUBMED

Bangari DS and Mittal SK. 2006. Development of nonhuman adenoviruses as vaccine vectors. Vaccine. 24(7):849-62. PUBMED

Kiupel M, Stevenson GW, Galbreath EJ, North A, HogenEsch H, and Mittal SK. 2005. Porcine circovirus type 2 (PCV2) causes apoptosis in experimentally inoculated BALB/c mice. BMC Vet Res. 1:7. PUBMED

Bangari DS, Sharma A, Mittal SK. 2005. Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3. Biochem Biophys Res Commun. 331(4):1478-84. PUBMED

Bangari DS, Mittal SK. 2005. Porcine adenovirus serotype 3 internalization is independent of CAR and alpha(v)beta(3) or alpha(v)beta(5) integrin. Virology 332:157-166. AUTHOR MANUSCRIPT PUBMED

Bangari DS, Shukla S, Mittal SK. 2005. Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture. Biochem.Biophys.Res.Commun. 327:960-966. AUTHOR MANUSCRIPT PUBMED

Noblitt LW, Bangari DS, Shukla S, Mohammed S, Mittal SK. 2005. Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy. Cancer Gene Therapy.12.(1):46.-53., 2005.Jan.46-53. AUTHOR MANUSCRIPT PUBMED

Noblitt LW, Bangari DS, Shukla S, Knapp DW, Mohammed S, Kinch MS, Mittal SK. 2004. Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1. Cancer Gene Therapy.11(11):757.-766., 2004.Nov.757-766. AUTHOR MANUSCRIPT PUBMED

Bangari DS, Mittal SK. 2004. Porcine adenoviral vectors evade preexisting humoral immunity to adenoviruses and efficiently infect both human and murine cells in culture. Virus Res. 105:127-136. AUTHOR MANUSCRIPT PUBMED

Sailaja, G., HogenEsch, H., North, A., Hays, J., and Mittal, S. K. (2002). Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector specific immune response. Gene Ther. 9:1722-1729. PUBMED

Choi J, Stevenson GW, Kiupel M, Harrach B, Anothayanontha L, Kanitz CL and Mittal SK. (2002) Sequence analysis of old and new strains of porcine circovirus associated with congenital tremors in pigs and their comparison with strains involved with postweaning multisystemic wasting syndrome. Can J Vet Res. Oct;66(4):217-24. PUBMED

van Olphen, A. and Mittal, S. K. (2002). Development and characterization of bovine x human hybrid cell lines that efficiently support the replication of both wild-type and e1-deleted bovine and human adenoviruses. J. Virol. 76: 5882-5892. PUBMED

van Olphen, A. and Mittal, S. K. (2002). A 72 bp internal deletion in the left inverted terminal repeat of bovine adenovirus type 3 genome does not affect virus replication. Intervirology 45:188-192. PUBMED

van Olphen, A., Tikoo, S. K. and Mittal, S. K. (2002). Characterization of bovine adenovirus type 3 early region 1 (E1) proteins and isolation of E1 expressing cell lines. Virology 295:108-118. PUBMED

Stevenson GW, Kiupel M, Mittal SK, Choi J, Latimer KS, and Kanitz CL. (2001) Tissue distribution and genetic typing of porcine circoviruses in pigs with naturally occurring congenital tremors. J Vet Diagn Invest. Jan;13(1):57-62. PUBMED

Kiupel M, Stevenson GW, Choi J, Latimer KS, Kanitz CL, and Mittal SK. (2001). Viral replication and lesions in BALB/c mice experimentally inoculated with porcine circovirus isolated from a pig with postweaning multisystemic wasting disease.Vet Pathol. 38(1):74-82. PUBMED

Aggarwal, N. and Mittal, S. K. (2000). Sequence analyses of porcine adenovirus type 3 E1 region, pIX, and pIVa2 genes. Intervirology 43:6-12. PUBMED

Mittal SK, Aggarwal N, Sailaja G, van Olphen A, HogenEsch H, North A, Hays J, and Moffatt S. (2000). Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine 19:253-263. AUTHOR MANUSCRIPT PUBMED

Moffatt, S., HogenEsch, H., Hays, J., and Mittal, S. K. (2000). Circumvention of vector-specific antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy. Virology 272:159-167. PUBMED

Aggarwal, N., HogenEsch, H., Guo, P., Adam North, Suckow, M. and Mittal, S. K. (1999). Biodegradable alginate microspheres as a delivery system for naked DNA. Can. J. Vet. Res. 63:148-152. PUBMED

van Olphen, A. L. and Mittal, S. K. (1999). Generation of infectious genome of bovine adenovirus type 3 by homologous recombination in bacteria. J. Virol. Methods 77:125-129. AUTHOR MANUSCRIPT PUBMED

Stevenson GW, Kiupel M, Mittal SK, and Kanitz CL. (1999). Ultrastructure of porcine circovirus in persistently infected PK-15 cells.Vet Pathol. 36(5):368-78. PUBMED

Mittal SK, Tikoo SK, Van Donkersgoed J, Beskorwayne T, Godson DL, and Babiuk LA. (1999). Experimental inoculation of heifers with bovine adenovirus type 3.Can J Vet Res. 63(2):153-6. PUBMED

Kuipel M, Stevenson GW, Kanitz CL, Anothayanontha L, Latimer KS and Mittal SK. (1999). Cellular localization of porcine circovirus in postweaning pigs with chronic wasting disease. Eur J Vet Path. 5(3):77-82.

Mittal, S. K., Tikoo, S. K., van den Hurk, J. V., Breker-Klassen, M. M., Yoo, D. and Babiuk, L. A. (1998). Functional characterization of bovine parainfluenza virus type 3 hemaggutinin-neuraminidase and fusion proteins expressed by adenovirus recombinants. Intervirology 41:253-260. PUBMED

Kiupel M, Stevenson GW, Mittal SK, Clark EG, and Haines DM. (1998). Circovirus-like viral associated disease in weaned pigs in Indiana.Vet Pathol. 35(4):303-7. PUBMED

Papp, Z., Middleton, D. M., Mittal, S. K., Babiuk, L. A. and Baca-Estrada, M. E. (1997). Mucosal immunization with recombinant adenovirus vectors: Induction of immunity and protection against respiratory bovine herpesvirus type 1 in the cotton rat model. J. Gen. Virol. 78:2933-2943. PUBMED

Mittal, S. K., Middleton, D. M., Tikoo, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1996). Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model following infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene. J. Gen. Virol. 77:1-9. PUBMED

Torres, J. M., Alonso, C., Ortega, A., Mittal, S. K., Graham, F. L. and Enjuanes, L. (1996).Tropism of human adenovirus 5 based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus. J. Virol. 70: 3770-3780. PDF

Mittal, S. K., Papp, Z., Tikoo, S. K., Baca-Estrada, M., Yoo, D., Benko, M. and Babiuk, L. A. (1996). Induction of systemic and mucosal immune responses in cotton rats immunized with human adenovirus type 5 recombinants expressing the full and secretory forms of bovine herpesvirus type 1 glycoprotein gD. Virology 222:299-309. PUBMED

Mittal, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1995). Development of a bovine adenovirus-based expression vector. J. Gen. Virol. 76:93-102 ABSTRACT

Breker-Klassen, M. M., Yoo, D., Mittal, S. K., Sorden, S. D., Haines, D. M. and Babiuk, L. A. (1995). Recombinant adenoviruses type 5 expressing bovine parainfluenza virus type 3 glycoproteins protect Sigmodon hispidus cotton rats from bovine parainfluenza virus type 3 infection. J. Virol. 69:4308-4315.23. PUBMED

Mittal, S. K., Bett, A. J., Prevec, L. and Graham, F L. (1995). Foreign gene expression by human adenovirus type 5 based vectors studied using firefly luciferase and bacterial beta-galactosidase genes as reporters. Virology 210:226-230. PUBMED

Mittal, S. K., Middleton, D. M., Tikoo, S. K. and Babiuk, L. A. (1995). Pathogenesis and immunogenicity of bovine adenovirus type 3 in cotton rats (Sigmodon hispidus). Virology 213:131-139. PUBMED

Zheng, B., Mittal, S. K., Graham, F. L. and Prevec, L. (1994). The E1 sequence of bovine adenovirus type 3 and complementation of human adenovirus type 5 E1A function in bovine cells. Virus Res. 31:163-186. PUBMED

Mittal, S. K., McDermott, M. R., Johnson, D. C., Prevec, L. and Graham, F. L. (1993). Monitoring foreign gene expression by a human adenovirus-based vector using the firefly luciferase gene as a reporter. Virus Res. 28:67-90. PUBMED

Braciak, T. A., Mittal, S. K., Graham, F. L., Richards, C. D. and Gauldie, J. (1993). Construction of recombinant human type 5 adenoviruses expressing rodent IL-6 genes: an approach to investigate in vivo cytokine function. J. Immunol. 151:5145-5153. PUBMED

Ruigrok RW, Barge A, Mittal SK and B Jacrot. The fibre of bovine adenovirus type 3 is very long but bent. J Gen Virol 1994 75: 2069-2073.

    BOOK CHAPTERS

    Mittal, S. K., HogenEsch, H. and Park, K. (2002). Vaccines and other Immunological Products. In: Encyclopedia of Pharmaceutical Technology. 2nd Ed.,Vol. 1. pp 2895-2916. J. Swarbrick and J. C. Boylan (Eds.), Marcel Dekker, Inc.

    Mittal, S. K., McDermott, M. R., Johnson, D. C., Prevec, L., Zamb, T., Babiuk, L. A. and Graham, F. L. (1994). Adenovirus based expression vectors for recombinant vaccines. In: Recombinant and Synthetic Vaccines. G. P. Talwar et al. (Eds.), Springer- Verlag, New York, NY, pp. 362-366.

    Mittal, S. K. (1992). Mutagenesis and protein engineering techniques. In: Food Biotechnology: Techniques and Applications. G. S. Mittal (Au.), Technomic Publishing Co. Inc., Lancaster, PA, pp. 119-132.

    Mittal, S. K. (1992). Genetic engineering techniques. In: Food Biotechnology: Techniques and Applications. G. S. Mittal (Au.), Technomic Publishing Co. Inc., Lancaster, PA, pp. 7-86.