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Borgens,
Richard B., Ph.D.
Director, Center for Paralysis Research.
Professor of Developmental Anatomy.
B.S. ‘70, North Texas State University; M.S. ‘73,
North Texas State University; PhD ‘77 Purdue University
E-mail:cpr@vet.purdue.edu
Research Interests:
Research interests lie in animal regeneration
and its physiological control. Various model systems have
been employed in this laboratory including studies of limb
regeneration and development, the regeneration of eyes in
gastropos molluscs, CNS regeneration in guinea pig models,
and the regeneration of peripheral nerve in electroreceptors
in the glass catfish. One control mechanism of interest is
the endogenous electrical (ionic) control of the regeneration
of weak DC fields to naturally occurring cases of canine paraplegia.
Publications
Borgens RB, Bohnert D,
Duerstock B, Spomar D, Lee RC. Related Articles, Links
Subcutaneous tri-block copolymer produces recovery from spinal
cord injury.
J Neurosci Res. 2004 Apr 1;76(1):141-54.
Borgens RB. Restoring function
to the injured human spinal cord.
Adv Anat Embryol Cell Biol. 2003;171:III-IV, 1-155. Review.
Duerstock BS, Bajaj CL, Borgens
RB. A comparative study of the quantitative accuracy
of three-dimensional reconstructions of spinal cord from serial
histological sections.
J Microsc. 2003 May;210(Pt 2):138-48.
Altizer AM, Stewart SG, Albertson BK, Borgens
RB. Skin flaps inhibit both the current of injury
at the amputation surface and regeneration of that limb in
newts. J Exp Zool. 2002 Oct 1;293(5):467-77.
Duerstock BS, Borgens RB.
Three-dimensional morphometry of spinal cord injury following
polyethylene glycol treatment. J Exp Biol. 2002 Jan;205(Pt
1):13-24.
Borgens RB, Shi R, Bohnert
D. Behavioral recovery from spinal cord injury following delayed
application of polyethylene glycol. J Exp Biol. 2002 Jan;205(Pt
1):1-12.
Shi, R, Borgens, R.B. Anatomical
repair of nerve membranes in crushed mammalian spinal cord
with polyethylene glycol. J. Neurocytology 29:633-644.
Leskovar, A., Turek, J, Borgens,
R.B. (2001) Giant multinucleated macrophages occur
in acute spinal cord injury. Cell Tissue Res 304:311-315.
Borgens, R.B. (2001) Cellular
Engineering: Molecular Repair of Membranes to Rescue Cells
of the Damaged Nervous System. Neurosurgery 49:1-9.
Duerstock, B.S., Bajaj, C.L., Pascucci,
V., Schikore, D., Lin, K-N., and Borgens, R.B.
(2000). Advances in three-dimensional reconstructions of the
experimental spinal cord injury. Computer Medical Imaging
and Graphics 24 (6), 389-406.
Leskovar, A., Moriarty, L.J., Turek, J.,
Schoenlein, I.A., and Borgens, R.B. (2000)
The Macrophage in Acute Neural Injury: Changes in Cell Numbers
Over Time and Levels of Cytokine Production in Mammalian Central
and Peripheral Nervous Systems J. Exp. Bio 203:1783-1795.
Borgens, R.B. and Shi,
R. (2000) Immediate recovery from spinal cord injury through
molecular repair of nerve membranes with polyethylene glycol.
FASEB 14:27-35.
Shi, R., Borgens, R.B.,
Blight, A.R. (1999) Functional Reconnection of Severed Mammalian
Spinal Cord Axons with Polyethylene Glycol. J. Neurotrauma
16:727-738.
Borgens, R.B., Toombs,
J.P., Breur, G., Widmer, W.R., Water, D., Harbath, A.M., March,
P., and Adams, L.G. (1999) An Imposed Oscillating Electrical
Field Improves the Recovery of Function in Neurologically
Complete Paraplegic Dogs. J. Neurotrauma 16:639-657.
Shi, R. and Borgens, R.B.
(1999) Acute repair of crushed guinea pig spinal cord by polyethylene
glycol. J. Neurophysiology, 81:2406-2414.
Moriarty, L.J. Duerstock, B.S., Bajaj, C.L.,
Lin. K., and Borgens, R.B. (1998) Two and
Three Dimensional Computer Graphic Evaluation of the Subacute
Spinal Cord Injury. J. of Neurological Sciences 155:121-137.
Borgens, R.B. and Bohnert,
D.M. (1997) The Response of Mammalian Spinal Axons to an Applied
DC Voltage Gradient. Experimental Neurology 145:376-389.
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