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Hannon,
Kevin M., Ph.D.
Associate Professor of Developmental Anatomy.
BS ‘85, Purdue University; MS ‘87, Iowa State
University; PhD ‘90, Iowa State University
Research Interests:
Developmental biology, growth factor biology,
molecular biology.
Skeletal muscle atrophy, a decrease in muscle
size and strength, is a sequela of many different diseases
and states (e.g., cancer, heart disease and stroke, and aging).
Atrophy progressively robs a person of his/her ambulatory
function, thereby markedly diminishing the quality of life
of millions of Americans each year. Age-associated atrophy
often necessitates costly nursing care, and disease-associated
atrophy both increases hospitalization time and extends requirements
for regenerative therapy. Thus, in addition to quality of
life issues, skeletal muscle atrophy is an important factor
that drives up the cost of medical care. The long-range goal
of our laboratory is to discover potential treatments and
interventions for skeletal muscle atrophy. To date, we have
found specific growth factors that stimulate the growth, size
and strength of skeletal muscles in vivo. It is expected that
these growth factors will provide the means to prevent and/or
treat skeletal muscle atrophy associated with aging and disease.
In addition, we have identified growth factors that significantly
inhibit the growth of, and actually simulate degeneration
of, skeletal muscle in vivo. In order to design the most optimal
approached for the prevention and treatment of skeletal muscle
atrophy, it may be necessary to consider inhibiting mechanisms
that are responsible for myofiber degeneration.
Publications
Alzghoul, M.B., D. Gerrard, B.A. Watkins
and K. Hannon. 2004. Ectopic Expression of
IGF-I and Shh by Skeletal Muscle Inhibits Disuse-Mediated
Skeletal Muscle Atrophy and Bone Osteopenia In Vivo. FASEB
J. Jan; 18(1): 221-3. Epub 2003 Nov 03.
Taylor, J., Babbs, C.F., Alzghoul, M.B.,
Olsen, A., Latour, M., Pond, A.L., and K. Hannon.
2004. Optimization of ectopic gene expression in skeletal
muscle through DNA transfer by electroporation. BMC Biotechnology.
Ward, P, K. Clase and K. Hannon.
2003. FGF10 Stimulates myogenesis in vitro but not in vivo.
Journal of Animal and Veterinary Advances: 2(4) 196-201.
Mitchell, P., S.E. Johnson and K.
Hannon.
2002. IGF-1 Stimulates Primary Myofiber Development During
Limb Development. Developmental Dynamics: 223:12-23.
Clase, K. P., Mitchell, P. Ward, C. Dorman,
S. Johnson, and K. Hannon. 2000. FGF5 Stimulates
Connective Tissue Development and Inhibits Skeletal Muscle
Development in the Limb: Developmental Dynamics: 219:368-380.
Steenstrup, T. and K. Hannon.
2000. Fusion alters mitogenic response of BC3H1 muscle cells.
In Vitro Developmental Biology:36:241-248.
Flanagan-Steet*, H., K. Hannon*,
M. McAvoy, R. Hullinger, B. B. Olwin. 2000. Loss of FGF Receptor
1 Signaling Reduces Skeletal Muscle Mass and Disrupts Myofiber
Organization in the Developing Limb. Developmental Biology,
Vol. 218, No. 1, pp. 21-37 (*indicates equal contributors,
listed alphabetically).
Steenstrup, T. and K. Hannon.
2000. Rapid Quantification of Cell Numbers by Use of Computer
Images. Biotechniques: 28: 625-627.
Mitchell, P., T. Steenstrup, and K.
Hannon. 1999. Expression of FGFs during post-natal
skeletal muscle hypertrophy. J. Appl. Phys., 86:313-319.
Hannon, K., Kudla, A.J.,
McAvoy, M., Clase, K.L., and Olwin, B.B. (1996) Differentially
expressed fibroblast growth factors regulate skeletal muscle
development through autocrine and paracrine mechanisms, J.
Cell. Biol., 132:1151-1159.
DeHamer, M.K., Geuvara, J.L., Hannon,
K., Olwin, B.B., and Calof, A.L. (1994) Fibroblast
Growth Factors Promote Amplifying Divisions of Olfactory Receptor
Neuron Precursors, Neuron, 13:1083-1097.
Hannon, K., Johnstone,
E., Craft, L.S., Little, S.P., Smith II, C.K., Heiman, M.L.,
and Santerre, R.F. (1993) Synthesis of PCR-derived, single-stranded
DNA probes suitable for in situ hybridization, Analytical
Biochem., 212:421-427.
Santerre, R.F., Bales, K.R., Janney, J.J.,
Hannon, K., Fisher, L.F., Bailey, C.S., Morris,
J.,Ivarie, R., and Smith II, C.K. (1993) Expression of bovine
myf5 induces ectopic skeletal muscle formation in transgenic
mice, Mol. Cell. Biol., 13:6044-6051.
Hannon, K., Smith II, C.K.,
Bales, K.R., and Santerre, R.F. (1992) Temporal and quantitative
expression of myogenic regulatory and growth factor genes
in the developing mouse, Developmental Biology, 151:137-145.
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