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Leary,
James F. ,
Ph.D.
Professor of Basic Medical Sciences and Biomedical Engineering
Schools of Veterninary Medicine and Weldon School of Biomedical Engineering
Member: Birck Nanotechnology Center, Bindley Biosciences Center, Oncological Sciences Center, Purdue Cancer Center
Purdue University
West Lafayette, IN 47909-2026
Phone: 765-494-7280
Fax: 765-494-0781
Email: jfleary@purdue.edu
Education/Training:
- S.B. Aeronautics/Astronautics, M.I.T.
1970;
- S.B. Humanities (Philosophy/History) M.I.T.
1970
- M.S. Physics Univ. of New Hampshire
1974
- Ph.D. Biophysics Penn State University
1977
- Post-doctoral Fellow Los Alamos National
Laboratory; (Cytometry/Immunology) 1978
Overview of Research:
Nanomedicine approaches to cancer diagnostics and therapeutics, antiviral therapies, and regenerative medicine; high-throughput and BioMEMS cell analysis and separation technologies for genomics and proteomics (cytomics) and drug discovery; high-speed imaging/laser ablation/laser opto-injection technologies for stem cell engineering
Scholarly Interest:
Our highly interdisciplinary laboratory and collaborators use quantitative single cell analysis techniques and technologies to study a number of interdisciplinary problems in the areas of nanomedicine, regenerative medicine, genomics, proteomics, drug discovery and stem cell engineering.
Publications
1. Yang, X., Li, X.,
Prow, T.W. Reece, L.M., Bassett, S.E., Luxon, B.A., Herzog,
N.K., Aronson, J., Shope, R.E., Leary, J.F., Gorenstein,
D.G. "Immunofluorescence Assay
and Flow Cytometric Selection of Bead Bound Aptamers" Nucleic
Acids Research 31 (10): 1-8, 2003.
2. Prow,T.W., Salazar,
J.H., Rose, W.A., Smith, J.N., Reece, L.M., Fontenot, A.A.,
Wang, N.A., Lloyd, R.S., Leary, J.F. "Nanomedicine - nanoparticles, molecular
biosensors and targeted gene/drug delivery for combined single-cell
diagnostics and therapeutics" Proc. of SPIE 5318: 1-11,
2004.
3 . Szaniszlo, P.,
Wang, N., Sinha, M., Reece, L.M., Van Hook, J.W., Luxon,
B.A., Leary, J.F. "Getting the Right Cells to the Array: Gene
Expression Microarray Analysis of Cell Mixtures and Sorted
Cells" Cytometry 59A: 191-202, 2004.
4. Valet, G., Leary,
J.F., Tárnok,
A. " Cytomics - New Technologies: Towards a Human
Cytome Project" Cytometry 59A: 167-171, 2004.
5. Prow, T.W.,
Kotov, N.A., Lvov, Y.M., Rijnbrand, R., Leary, J.F. "Nanoparticles, Molecular Biosensors,
and Multispectral Confocal Microscopy" Journal of Molecular
Histology, Vol. 35, No.6, pp. 555-564, 2004.
6. Smith, J.N.,
Reece, L.M., Szaniszlo, P., Leary, R.C. Leary, J.F. "Subtractive Clustering
Analysis: A Novel Data Mining Method for Finding Cell Subpopulations" Proc.
of SPIE 5699: 354 - 361, 2005.
7. Leary, J.F.,
Reece, L.M., Yang, X., Gorenstein., D.G. "High-Throughput Flow Cytometric
Screening of Combinatorial Chemistry Bead Libraries for Proteomics
and Drug Discovery" Proc. of SPIE 5692: 216 - 223, 2005.
8. Prow, T.W.,
Rose, W.A., Wang, N., Reece, L.M., Lvov, Y., Leary, J.F. "Biosensor-Controlled Gene
Therapy/Drug Delivery with Nanoparticles for Nanomedicine" Proc.
of SPIE 5692: 199 - 208, 2005.
9. Leary, J.F. "Ultra High
Speed Cell Sorting" Cytometry (In press) 2005
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