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Amber
Pond, Ph.D.
Research Scientist
PhD ‘95, Missippi State University, 1995
E-mail:pond@purdue.edu
Research Interests
The IKr potassium current is critical for
repolarization of cardiac action potentials. The ERG1 gene
encodes the channel proteins responsible for IKr. Mutations
in this gene have been linked to Long QT Syndrome, an inherited
and acquired cardiac disease that can cause syncope, seizures
and sudden death. We study the developmental differences in
expression and function of ERG1 splice variants in mice. Understanding
these differences will allow researchers to recapitulate physiological
IKr current in vitro and, therefore, develop better therapeutic
strategies for diseases resulting from aberrant repolarization.
Additionally, we have recently teamed with the laboratory
of Dr. Kevin Hannon and together are researching the roles
of potassium channels in skeletal muscle function.
Publications
Jiang M, Zhang M, Tang DG, Clemo HF, Liu
J, Holwitt D, Kasirajan V, Pond AL, Wettwer
E, Tseng GN. KCNE2 protein is expressed in ventricles of different
species, and changes in its expression contribute to electrical
remodeling in diseased hearts.
Circulation. 2004 Apr 13;109(14):1783-8. Epub 2004 Apr 05
Taylor J, Babbs CF, Alzghoul MB, Olsen A,
Latour M, Pond AL, Hannon K. Optimization
of ectopic gene expression in skeletal muscle through DNA
transfer by electroporation. BMC Biotechnol. 2004 May 18;4(1):11.
Le Bouter S, Demolombe S, Chambellan A,
Bellocq C, Aimond F, Toumaniantz G, Lande G, Siavoshian S,
Baro I, Pond AL, Nerbonne JM, Leger JJ, Escande
D, Charpentier F. Microarray analysis reveals complex remodeling
of cardiac ion channel expression with altered thyroid status:
relation to cellular and integrated electrophysiology. Circ
Res. 2003 Feb 7;92(2):234-42.
Pond AL, Nerbonne JM. ERG
proteins and functional cardiac I(Kr) channels in rat, mouse,
and human heart. Trends Cardiovasc Med. 2001 Oct;11(7):286-94.
Review.
Pond AL, Scheve BK, Benedict
AT, Petrecca K, Van Wagoner DR, Shrier A, Nerbonne JM. Expression
of distinct ERG proteins in rat, mouse, and human heart. Relation
to functional I(Kr) channels. J Biol Chem. 2000 Feb 25;275(8):5997-6006.
Van Wagoner DR, Pond AL,
Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM.
Atrial L-type Ca2+ currents and human atrial fibrillation.
Circ Res. 1999 Sep 3;85(5):428-36.
Pond AL, Chambers HW, Coyne
CP, Chambers JE. Purification of two rat hepatic proteins
with A-esterase activity toward chlorpyrifos-oxon and paraoxon.
J Pharmacol Exp Ther. 1998 Sep;286(3):1404-11.
Van Wagoner DR, Pond AL,
McCarthy PM, Trimmer JS, Nerbonne JM. Outward K+ current densities
and Kv1.5 expression are reduced in chronic human atrial fibrillation.
Circ Res. 1997 Jun;80(6):772-81.
Peebles ED, Pond AL, Thompson
JR, McDaniel CD, Cox NM, Latour MA. Naloxone attenuates serum
corticosterone and augments serum glucose concentrations in
broilers stimulated with adrenocorticotropin. Poult Sci. 1997
Mar;76(3):511-5.
Latour MA, Laiche SA, Thompson JR, Pond
AL, Peebles ED. Continuous infusion of adrenocorticotropin
elevates circulating lipoprotein cholesterol and corticosterone
concentrations in chickens. Poult Sci. 1996 Nov;75(11):1428-32.
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