Purdue University

Jerry Kendell Davis, D.V.M., Ph.D. Director, Veterinary Laboratory Animal Program School of Veterinary Medicine Purdue University West Lafayette, IN 47907 Phone: 765-494-1234 Email: davis39@purdue.edu Webpage: http://www.vet.purdue.edu/iuplam/

Education

Awards and Honors

Overview of Research

Animal Medicine
    Laboratory animal medicine, infectious disease, and animal models.

Publications

Refereed journals

Cassell, G.H. and Davis, J.K.: Protective effect of vaccination against mycoplasma respiratory disease in rats. Infect. Immun. 21:69-75, 1978.

Cassell, G.H., Davis, J.K., Wilborn, W.H., and Wise, K.S.: Pathobiology of mycoplasmas. In: Microbiology, 1978. Schlesinger, D. ed. Am. Soc. Microbiol., Washington, D.C., pp. 399-403, 1978.

Cassell, G.H., Lindsey, J.R., Baker, H.J., and Davis, J.K.: Mycoplasmal and rickettsial diseases. In: The Laboratory Rat. Vol. 1., H.J. Baker, J.R. Lindsey, and S.H. Weisbroth, eds. Academic Press, Inc., N.Y., pp. 243-269, 1979.

Davis, J.K., Delozier, K.M., Asa, D.K., Minion, F.C., and Cassell, G.H.: Interactions between murine alveolar macrophages and Mycoplasma pulmonis in vitro. Infect. Immun. 29:590-599, 1980.

Davis, J.K., Maddox, P.A., Thorp, R.B., and Cassell, G.H.: Immunofluorescent characterization of lymphocytes in lungs of rats infected with Mycoplasma pulmonis. Infect. Immun. 27:255-259, 1980.

Cassell, G.H., Davis, J.K., and Lindsey, J.R.: Control of Mycoplasma pulmonis infection in rats and mice: detection and elimination vs. vaccination. Isr. J. Med. Sci. (Special suppl.) 17:674-677, 1981.

Cassell, G.H., Davis, J.K., Lindsey, J.R., Cole, B.C., and Hartley, M.W.: Arthritis of rats and mice: Implications for man. Isr. J. Med. Sci. 17:608-615, 1981.

Cassell, G.H., Lindsey, J.R., and Davis, J.K.: Respiratory and genital mycoplasmosis of laboratory rodents: Implications for biomedical research. Isr. J. Med. Sci. (Special Suppl.) 17:548-554, 1981.

Cassell, G.H., Lindsey, J.R., Davis, J.K., Davidson, M.K., Brown, M.B., and Mayo, J.G.: Detection of natural Mycoplasma pulmonis infection in rats and mice by an enzyme-linked immunosorbent assay (ELISA). Lab. An. Sci. 31:676-682, 1981.

Davis, J.K., Cassell, G.H., Minion, F.C., and Wise, K.S.: Mycoplasma host-cell interactions resulting in chronic inflammation: Acquisition of host antigens and other mechanisms. Isr. J. Med. Sci. 17:633-636, 1981.

Davis, J.K. and Cassell, G.H.: Murine respiratory mycoplasmosis in LEW and F344 rats: strain differences in lesion severity. Vet. Path. 19:280-293, 1982.

Davis, J.K., Thorp, R.B., Maddox, P.A., and Cassell, G.H.: Murine respiratory mycoplasmosis(MRM) in F344 and LEW rats. Evolution of lesions and lung lymphoid cell populations. Infect. Immun. 36:720-729, 1982.

Brown, M.B., Minion, F.C., Davis, J.K., Pritchard, D.G., and Cassell, G.H.: Antigens of Mycoplasma hominis. Sex. Trans. Dis. 10:247-255, 1983.

Cassell, G.H., Brown, M.B., Younger, J.B., Blackwell, R.F., Davis, J.K, Marriott, P., and Stagno, S.: Incidence of genital mycoplasmas in women at the time of diagnostic laparoscopy. Yale J. Biol. Med. 56:557-563, 1983.

Cassell, G.H., Davidson, M.K., Davis, J.K., Lindsey, J.R.: Recovery and identification of murine mycoplasmas. In: Methods in Mycoplasmology, Vol. II, Tulley, J.G., Razin, S.H., eds., Academic Press, N.Y., pp. 129-142, 1983.

Cassell, G.H., Davis, J.K., Lindsey, J.R., Davidson, M.K., Brown, M.B., and Baker, H.J.: Detection of Mycoplasma pulmonis Infections by ELISA. Lab. Ani. 12:27-38, 1983.

Cassell, G.H., Davis, R.O, Waites, K.B., Brown, M.B., Marriott, P.M., Stagno, S., and Davis, J.K.: Isolation of Mycoplasma hominis and Ureaplasma urealyticum from amniotic fluid at 166-20 weeks gestation: Potential effect on pregnancy outcome. Sex Trans. Dis. 10:294-302, 1983.

Cassell, G.H., Younger, J.B., Blackwell, R.E., Davis, J.K., Brown, M.B., Marriott, P.M. and Stagno, S.: Microbiologic study of infertile females at time of diagnostic laparoscopy: Association of Ureaplasma urealyticum with a defined subpopulation. N. Eng. J. Med. 308:502-506, 1983.

Cassell, G.H., Davis, J.K., Cox, N.R., Davidson, M.K., and Lindsey, J.R.: Mycoplasma pulmonis detection in rodents: Lesson for diagnosis in other species. Isr. J. Med. Sci. 20: 859-865, 1984.

Cassell, G.H., Clyde, W.A., Davis, J.K.:Mycoplasmal Respiratory Infections. In: The Mycoplasmas, Vol. IV, Mycoplasma Pathogenicity, S. Razin and M.F. Barile (eds). Academic Press, Inc., N.Y., pp. 69-107, 1985.

Davis, J.K., Parker, R.F., White, H., Dziedzic, D., Taylor, G., Davidson, M.K., Cox, N.R., and Cassell, G.H.: Strain differences in susceptibility to murine respiratory mycoplasmosis in C57BL/6 and C3H/HeN mice. Infect. Immun. 50:647-654, 1985.

Davis, J.K., Simecka, J.W., Williamson, J.S.P., Ross, S.E., Juliana, M.M., Thorp, R.B., and Cassell, G.H.: Nonspecific lymphocyte responses in F344 and LEW rats: susceptibility to murine respiratory mycoplasmosis and examination of cellular basis for strain differences. Infect. Immun. 49:152-158, 1985.

Cassell, G.H., Cox, N.R., Davis, J.K., Brown, M.B., Minion, F.C., and Lindsey, J.R.: State-of-the-art detection methods for rodent mycoplasmas. In: Complications of Viral and Mycoplasmal Infections in Rodents to Toxicology Research and Testing. 6th CIIT Conference on Toxicology held Feb. 8-9, 1983 in Raleigh, N.C. Edited by Thomas E. Hamm, Jr., Chemical Industry Institute of Toxicology. Hemisphere Publishing Corporation, Washington, D.C., pp. 143-160, 1986.

Cassell, G.H., Davis, J.K., Simecka, J.W., Lindsey, J.R., Cox N.R., Ross, S., and Fallon, M.: Mycoplasmal infections: Disease Pathogenesis, implications for biomedical research, and control. In: Viral and Mycoplasmal Infections in Laboratory Rodents: Effects on Biomedical Research, P.M. Bhatt, R.O. Jacoby, H.C. Morse III, and A.E. New, eds. Academic Press, Inc., N.Y., pp. 87-130, 1986.

Cassell, G.H., Waites, K.B., Gibbs, R.S., and Davis, J.K.: Role of Ureaplasma urealyticum in amnionitis. Pediatr. Infect. Dis. 5:S247-S252, 1986.

Davis, J.K., Thorp, R.B., Parker, R.F., White, H., Dziedzic, D., D'Arcy, J., and Cassell, G.H.: Development of an aerosol model of murine respiratory mycoplasmosis in mice. Infect. Immun. 54:194-201, 1986.

Gibbs, R.S., Cassell, G.H., Davis, J.K., and St. Clair, P.J.: Further studies on genital mycoplasmas in intra-amniotic infection: Blood cultures and serologic response. Am. J. Obstet. Gynecol. 154:717-726, 1986.

Horowitz, S.A., Duffy, L. Garrett, B., Stephens, J., Davis, J.K., and Cassell G.H.: Can group- and serovar-specific proteins be detected in Ureaplasma urealyticum? Pediatr.Infect.Dis. 5(Suppl):S325-31. 1986.

Pinson, D.M., Schoeb, T.R., Lindsey, J.R., and Davis, J.K.: Evaluation by scoring and computerized morphometry of lesions of early Mycoplasma pulmonis infection and ammonia exposure in F344/N rats. Vet. Pathol. 23:550-555, l986.

Williamson, J.S.P., Davis, J.K., and Cassell, G.H.: Polyclonal activation of rat splenic lymphocytes after in vivo administration of Mycoplasma pulmonis and its relation to in vitro response. Infect. Immun. 52:594-599, 1986.

Simecka, J.W., Davis, J.K., and Cassell, G.H.: Distribution of Ia antigens and T lymphocyte Subpopulations in rat lungs. Immunol. 57:93-98, 1986.

Brown, M.B., Cassell, G.H., McCromack, W.M., and Davis, J.K.: Measurement of antibody to Mycoplasma hominis by an enzyme-linked immunoassay and detection of class-specific antibody responses in women with postpartum fever. Am. J. Obst. Gyne. 156:701-708, 1987.

Cassell, G.H., Davis, J.K., Waites, K.B., Rudd, P.T., Talkington, D., Crouse, D., and Horowitz, S.A.: Pathogenesis and significance of urogenital mycoplasmal infections. In: Urogenital Infections, J.M. Campos, and L.A. Miller, eds. Plenum Publishing Corporation, N.Y., pp. 93-115, 1987.

Davidson, M.K., Lindsey, J.R., and Davis, J.K.: Requirements and selection of an animal model. Isr. J. Med. Sci. 23:551-555, 1987.

Davis, J., Cassell, G.H., Gambill, G., Cox, N., Watson, H., and Davidson, M.: Diagnosis of murine mycoplasmal infections by enzyme-linked immunosorbent assay (ELISA). Isr. J. Med. Sci. 23:717-722, 1987.

Davis, J.K., Gaertner, D., Cox, N.C., Lindsey, J.R., Cassell, G.H., Davidson, M.K., Kervin, K.C., and Rao, G.N.: The role of Klebsiella oxytoca in utero-ovarian infection B6C3F1 mice. Lab. Ani. Sci. 37:159-166, 1987.

Horowitz, S.A., Garrett, B., Davis, J.K,, and Cassell, G.H.: Isolation of Mycoplasma pulmonis membranes and identification of surface antigens. Infect. Immun. 55:1314-1320, 1987.

Parker, R.F., Davis, J.K., Blalock, D.k., Thorp, R.B., Simecka, J.W., and Cassell, G.H: Pulmonary clearance of Mycoplasma pulmonis in C57BL/6N and C3H/HeN mice. Infect. Immun. 55:2631-2635, 1987.

Simecka, J.W., Davis, J.K., and Cassell, G.H.: Specific vs. nonspecific immune responses in murine respiratory mycoplasmosis. Isr. J. Med. Sci. 23:485-487, 1987.

Watson, H.L., Cox, N.R., Davidson, M.K., Blalock, D.K., Davis, J.K., Dybvig, K., Horowitz, S.A., and Cassell, G.H.: Mycoplasma pulmonis proteins common to murine mycoplasmas. Isr. J. Med. Sci. 23: 442-447, 1987.

Watson, H.L., Davidson, M.K., Cox, N.R., Davis, J.K., Dybvig, K., and Cassell, G.H.: Protein variability among strains of Mycoplasma pulmonis. Infect. Immun. 55:2838-2840, 1987.

Cassell, G.H., Crouse, D.T., Waites, K.B., Rudd, P.T. and Davis, J.K.: Does Ureaplasma urealyticum cause respiratory disease in newborns? Ped. Infect. Dis. 7:535-541, 1988.

Cassell, G.H., Waites, K.B., Horowitz, S.A. and Davis, J.K.: Mycoplasmal arthritis In: Infections in Rheumatic diseases. Lewis Espinoza, ed. Grune and Stratton. Page 235-241, 1988.

Cox, N.R., Davidson, M.K., Davis, J.K., and Cassell, G.H.: Natural mycoplasmal infections in isolator-maintained LEW/Tru Rats. Lab. Ani. Sci. 38(4):381-388, 1988.

Davidson, M.K., Davis, J.K., Lindsey, J.R. and Cassell, G.H.: Clearance of different strains of Mycoplasma pulmonis from the respiratory tract of C3H/HeN mice. Infect. Immun. 56:2163-2168, 1988.

Parker, R.F., Davis, J.K., Cassell, G.H., White, H., Dziedzic, D., Blalock, D.K., Thorp, R.B., and Simecka, J.W.: Short-term exposure to nitrogen dioxide enhances susceptibility to murine respiratory mycoplasmosis and decreases intrapulmonary killing of M. pulmonis. Am. Rev. Resp. Dis. 140:502-512, 1989. (Chosen to be abstracted in Pulmonary Disease, 1990. Green GM ed.)

Rudd, P.T., Cassell, G.H., Waites, K.B., Davis, J.K. and Duffy, L.B.: Ureaplasma urealyticum pneumonia: Experimental production and demonstration of age-related susceptibility. Infect. Immun. 57:918-925, 1989.

Simecka, J.W., Davis, J.K., and Cassell, G.H.: Serum antibody does not account for differences in the severity of chronic respiratory disease due to Mycoplasma pulmonis in LEW and F344 rats. Infect. Immun. 57:3570-3575, 1989.

Simecka, J.W., Patel, P., Davis, J.K., and Cassell, G.H.: Upper respiratory trat is the major site of antibody production in mycoplasmal induced chronic respiratory disease. Reg. Immunol. 2(6):385-389, 1989.

Davidson, M.K., Lindsey, J.R., Davis, J.K., Parker, R.F., Ross, S.E., Watson, H.L., Tully, J.G. and Cassell, G.H.: Alternative approach to identification of virulence mechanisms of Mycoplasma pulmonis. Zbl. Bakt. Suppl. 20. Recent Advances in Mycoplasmology, 695-697, 1990.

Davis, J.K., Parker, R.F., Davidson, M.K., Cassell, G.H., and Lindsey, J.R.: Pulmonary Clearance of Mycoplasma pulmonis in Mice. Zbl. Bakt. Suppl. 20. Recent Advances in Mycoplasmology, 819-822, 1990.

Ross, S.E., Davis, J.K., and Cassell, G.H.: Induction of hyper Ia antigen expression on F344 rat B lymphocytes by Mycoplasma pulmonis mitogen. Zbl. Bakt. Suppl. 20. Recent Advances in Mycoplasmology, 584-592, 1990.

Davis, J.K., Davidson, M.K. and Schoeb, T.R: Murine respiratory mycoplasmosis: a model to study effects of oxidants. Res. Rep. Health Eff. Inst. 1-29; discussion 31-43, 1991

Simecka, J.W., Patel, P., Davis, J.K., Ross, S.E., Otwell, P., Cassell, G.H.: Specific and nonspecific antibody responses in different segments of the respiratory tract in rats infected with Mycoplasma pulmonis. Infect. Immun. 59(10): 3715-3721, 1991.

Talkington, D.F., Davis, J.K., Canupp, K.C., Garrett, B.K., Waites, K.B., Huster, G.A., Cassell, G.H.: The effects of three serotypes of Ureaplasma urealyticum on spermatozoal motility and penetration in vitro. Fertil. Steril. 55(1): 170-176, 1991.

Subcommittee on Rodent Viral and Mycoplasmal Infections of the American Committee on Laboratory Animal Disease (ACLAD): Detection methods for the identification of rodent viral and mycoplasmal infections. Lab. Anim. Sci. 41(3):199-225, 1991 (Contributor and member of subcommittee).

Davis, J.K., Davidson, M.K., Schoeb, T.R., and Lindsey, J.R.: Decreased intrapulmonary killing of Mycoplasma pulmonis after short-term exposure to NO2 is associated with damaged alveolar macrophages. Am. Rev. Respir. Dis. 145:406-411, 1992.

McIntosh, J.C., Simecka, J.W., Ross, S.E., Davis, J.K., Miller, E.J., and Cassell, G.H.: Infection-induced airway fibrosis in two rat strains with differential susceptibility. Infect. Immun. 60(7):2936-2942, 1992.

Ross, S.E., Simecka, J.W., Gambill, G.P., Davis, J.K., and Cassell, G.H.: Mycoplasma pulmonis possesses a novel chemoattractant for B lymphocytes. Infect Immun . 60:669-674, 1992.

Nichols, P.W., Schoeb, T.R., Davis, J.K., Davidson, M. K., and Lindsey, J.R.: Pulmonary clearance of Mycoplasma pulmonis in rats with respiratory viral infections or of susceptible genotype. Lab Animal Sci. Lab. Anim. Sci. 42:1-4, 1992.

Simecka, J.W., Davis, J.K., Davidson, M.K., Ross, S.E., Stadtander, C.T.K.-H., and Cassell, G.H.: Mycoplasma diseases of animals. In Mycoplasmas: Molecular Biology and Pathogenesis. J. Maniloff, R. McElhaney, L. Finch, and J. Baseman eds. Am. Soc. Microbiology. 391-415, 1992.

Davidson, M.K., Davis, J.K., Gambill, G. P., Cassell, G. H., Lindsey, J.R. 1994. Mycoplasmas of laboratory rodents. In Mycoplasmosis in Animals: Laboratory Diagnosis. H. W. Whitford, R. F. Rosenbusch, L. H. Lauerman eds. Iowa State University Press, Ames IA.

Faulkner, C.B., Davidson, M.K., Davis, J.K., Schoeb, T.R., Simecka, J.W., and Lindsey, J.R.: Acute Mycoplasma pulmonis infection associated with coagulopathy in C3H/HeN mice. Lab. Animal Sci. 45:368-372, 1995.

Swing, S.P., Davis, J.K., and Egan, M.L.: In vitro effects of Mycoplasma pulmonis on murine natural killer cell activity. Lab. Animal Sci. 45:352-356, 1995.

Cartner, S.C., Simecka, J.W., Lindsey, J.R., Cassell, G.H., and Davis, J.K.: Chronic respiratory mycoplasmosis in C3H/HeN and C57Bl/6N mice: Lesion Severity and Antibody Response. Infect. Immun. 63:4138-4142, 1995.

Liang, S.C., Schoeb, T.R., Davis, J.K., Simecka, J.W., Cassell, G. H., and Lindsey, J.R.: Comparative severity of respiratory lesions of sialodacryoadenitis virus and Sendai virus infections in LEW and F344 rats. Vet Pathol. 32: 661-667, 1995.

Baumgartner, T.G., Henderson G.N., Davis, J.K., Mladinich, C., Samrag, G.P.N., Kubilis, P.S.: Study of the safety and Efficacy of using a LEA (Pall) filtration of propofol in 10% lipid emulsion (DiprivanTM) in the canine model. Final Study Report (Protocol 4298). 1995.

Faulkner CB, Simecka JW, Davidson MK, Davis JK, Schoeb TR, Lindsey JR, Everson MP. Gene expression and production of TNF- , IL-1, IL-6, and IFN- in C3H/HeN and C57BL/6N mice in acute Mycoplasma pulmonis disease. Infect Immun 63:4084-4090, 1995

Schoeb, T.R., Davis, J. K., Lindsey, J. R. Murine respiratory mycoplasmosis, rat and mouse. In International Life Sciences Institute Monographs on Pathology of Laboratory Animals: Respiratory System. T.C. Jones, U. Mohr, R.D. Hunt(eds.); Springer-Verlag, Berlin, 1996.

Schoeb TR, Davidson MK, Davis JK. Pathogenicity of cilia-associated respiratory (CAR) bacillus isolates for F344, LEW, and SD rats. Vet Pathol 34:263-270. 1997.

Schoeb TR, Dybvig K, Davidson MK, Davis JK. Detection of urogenital mycoplasma and ureaplasma infections in primates by polymerase chain reaction (PCR). Lab Anim Sci.47: 468-471.1997

Schoeb TR, Dybvig K, Davidson MK, Davis JK. Detection by nested PCR of Mycoplasma pulmonis in isolates of cilia-associated respiratory (CAR) bacillus and in respiratory tracts of rats. J Clin Microbiol 35:: 1667-1670.1997.

Boinski. S.; Swing, S.P.; Gross, T.P.; Davis, J.K. . Environmental enrichment of brown capuchins (Cebus apella): behavioral and plasma and fecal cortisol measures of effectiveness. American Journal of Primatology 47:1-20. 1999

Liang, S.-C., Simecka, J.W., Cassell, G.H., and Davis, J.K. Antibody responses after Sendai virus infection and their role in upper and lower respiratory tract disease in rats. Lab. Animal Sci. 49:385-394. 1999.

Reyes, L., Davidson, MK., Thomas, L. Davis, JK. Effects of Mycoplasma fermentans strain incognitus on differentiation of THP-1 cells. Infect. Immun. 67: 3188-319,.1999.

Boinski S.; Gross, T.P.; Davis, J.K.. Terrestrial predator alarm vocalizations are a valid monitor of stress in captive brown capuchins (Cebus apella). Zoo Biology. 18:295-312, 1999.

Davis, JK., Crouse, DT., Robertson, JA., Davidson, MK., Brown, MB., Reyes, L. The Role of Ureaplasma urealyticum in Human Reproductive and Neonatal Diseases. Infect Dis Rev 1(3):200-207.1999

Dohm, ED., Richards, DS, Robertson, JA., Theele, DP., Schoeb, TR., Davis, JK., Thomas, LC., Davidson, MK. Vertical Transmission of Ureaplasma urealyticum in Pregnant Pigtail Macaques (Macaca nemestrina). Infect Dis Rev 1(3):208-213.1999

Schoeb TR, Davis JK. Comment on "Barrier facilities for transgenic rodents in academic centers--a two-edged sword". Comp Med 53:116-8. 2003

Schleig, PM, Buergelt, CD, Davis, JK, Williams,E, Monif, GRG, and Davidson, MK. Attachment of Mycobacterium avium subspecies paratuberculosis to bovine intestinal organ Cultures: Method Development and Strain Differences. Vet Microbiol. 108: 271-279. 2005