Education

Overview of Research

Immunology and Hematopoiesis
    I am interested in studying trafficking, differentiation, and effector function of immune cells and their progenitor cells. Current studies in the lab include:

1. Roles of chemokines and chemokine receptors in trafficking of leukocytes in normal and diseased conditions such as cancer and autoimmune diseases
   
2. Functional genomics of germinal center T cells
   
3. Migration and function of regulatory T cells
   
4. Homing and differentiation of hematopoietic stem cells.
   

SELECTED PUBLICATIONS

• Hromas R., Kim CH, Klemsz M, Krathwohl M, Fife K, Cooper S, Schnizlein-Bick C and Broxmeyer. HE, Isolation and characterization of Exodus-2, a novel C-C chemokine with a unique 37-amino acid carboxyl-terminal extension. J. Immunol., 1997, 159: 2554-2558.

• Kim CH and Broxmeyer HE. In vitro behavior of hematopoietic progenitor cells under the influence of chemoattractants: SDF-1, Steel Factor and the bone marrow environment. Blood, 1998, 91:100-110.

• Kim CH, Pelus LM, White JR, Appelbaum E, Johanson K, and Broxmeyer HE, CKb-11/MIP-3b/ELC is an efficacious chemoattractant for T- and B-cells. J. Immunol., 1998, 160:2418-2424.

• Kim CH, Pelus LM, White JR, and Broxmeyer HE. Rapid communication: Differential chemotactic behavior of developing T cells in response to thymic chemokines. Blood, 1998, 91:4434-4443.

• Kim CH, Pelus LM, White JR, and Broxmeyer HE. MIP-3b/ELC/CKb-11, a CC chemokine, is a chemoattractant for myeloid progenitor cells with a specificity for macrophage progenitors. J. Immunol., 1998, 161:2580-2585.

• Broxmeyer HE and Kim CH (1999) Chemokines and hematopoiesis. In Chemokines and Cancer. B. J. Rollins, Ed. Humana Press, NJ, pp. 263-291.

• Kim CH and Broxmeyer HE. Chemokines: Signal lamps for trafficking of T- and B-cells for development and effector function. 1999, J. Leukoc. Biol., 65:6-15.

• Kim CH and Broxmeyer HE. (2000) Chemokines for immature blood cells: effects on migration, proliferation and differentiation. In Chemokines and Allergic Diseases. M. E. Rothenberg, Ed. Marcel Dekker, New York, NY, pp. 227-261.

• Kim CH and Broxmeyer HE. Thrombopoietin and interleukin-3 are chemotactic and chemokinetic chemoattractants for a factor-dependent hematopoietic progenitor cell line. Ann N Y Acad Sci., 1999, 872:395

• Kim CH and Broxmeyer HE, SLC/Exodus2/6Ckine induces chemotaxis of hematopoietic progenitor cells: Differential activity of ligands of CCR7, CXCR3, or CXCR4 in chemotaxis vs. suppression of progenitor proliferation. 1999, J. Leukoc. Biol., 66: 455-461.

• Broxmeyer HE, and Kim CH, Regulation of hematopoiesis in a sea of chemokine family members with a plethora of redundant activities. 1999, Exp. Hematol. 189:1987-92.

• Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.

• Youn BS, Kim CH, Smith F, Broxmeyer HE, TECK, an efficacious chemoattractant for human thymocytes, uses GPR-9-6/CCR9 as a specific receptor. 1999, Blood. 94:2533-2536.

• Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.

• Braun SE, Chen SE, Foster RG, Kim CH, Hromas R, Broxmeyer, HE, Cornetta K, The CC chemokine CKb-11/MIP-3b/ELC/Exodus3 mediatesnbsp tumor rejection of murine breast cancer cells through natural killer cells. 2000, J. Immunol. 164:4025.

• Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.

• Andrew DP, Ruffing N, Kim CH (co-first authors), Miao A, Heath H, You-Li, Murphy K, Butcher EC, Wu L, CCR4 expression defines a major subset of circulating non-intestinal memory T cells of both Th1 and Th2 potential. 2001, J. Immunol. 166:103.

• Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.

• Broxmeyer HE, Youn BS, Kim CH, Hangoc G, Cooper S and Mantel C. Chemokine regulation of hematopiesis and the involvement of pertussis toxin-sensitive Gai proteins. 2001, Ann N Y Acad Sci. 938:117-27.

• Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.

• Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881.

• Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.

• Kim CH, Campbell DJ, and Butcher EC, Nonpolarized memory T cells. 2001, Trends in Immunology. 22:527-530.

• Kim CH, Johnston Brent and Butcher EC, Trafficking machinery of NKT cells: differential chemokine receptor expression among NKT cell subsets with distinct cytokine-producing capacity. 2002, Blood. 2002;100:11-16.

• Roy M, Kim CH, Butcher EC. Cytokine regulation of B cell homing machinery. 2002, J. Immunol. 169:1676.

• Campbell DJ, Kim CH, Butcher EC. Chemokines in the systemic organization of immunity. Immunol Rev. 2003, 195:58-71.

• Broxmeyer HE, Cooper S, Kohli L, Hangoc G, Lee Y, Mantel C, Clapp DW, Kim CH. Transgenic Expression of Stromal Cell-Derived Factor-1/CXC Chemokine Ligand 12 Enhances Myeloid Progenitor Cell Survival/Antiapoptosis In Vitro in Response to Growth Factor Withdrawal and Enhances Myelopoiesis In Vivo. J. Immunol. 2003, 170:421-429.

• Kunkel EJ, Kim CH, Lazarus NH, Vierra MA, Soler D, Bowman EP, Butcher EC. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J Clin Invest. 2003, 111:1001-10.

• Broxmeyer HE, Kohli L, Kim CH, Lee Y, Mantel C, Cooper S, Hangoc G, Shaheen M,nbsp Li X, Clapp DW. Stromal cell-derived factor-1/CXCL12 directly enhances survival/antiapoptosis of myeloid progenitor cells through CXCR4 and Galphai proteins and enhances engraftment of competitive, repopulating stem cells. J Leukoc Biol. 2003, 73(5):630-638.

• Johnston B, Kim CH, Soler D, Emoto M, Butcher EC. Differential chemokine responses and homing patterns of murine TCRalphabeta NKT cell subsets. J Immunol. 2003, 171:2960-9.

• Kim CH, Butcher EC, Johnston B. Distinct subsets of human Va24-invariant NKT cells. 2002, Trends in Immunology, 23:516-9.

• Kim CH, Nagata K, and Butcher EC. Dendritic Cells Support Sequential Reprogramming of Chemoattractant Receptor Profiles During Naive to Effector T Cell Differentiation. J. Immunol. 2003. 171(1):152-8.

• Kim CH. Chemokine-chemokine receptor network in immune cell trafficking. 2004, Current Drug Target- Immune, Endocrine & Metabolic Disorders. 2004:4, 343-361.

• Kim CH and Johnson R. Trafficking potentials of unconventional T cell subsets. Current Medicinal Chemistry-Anti-Inflammatory & Anti-Allergy Agents. 2004, 3:321-340.

• Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T cells. 2004. Blood. 104: 1952-1960.

• Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004, J. Clin. Invest. 114:1640-1649.

• Kim CH. The greater chemotactic network for lymphocyte trafficking: Chemokines and beyond. Current Opinion in Hematology 2005, 12:298-304.

• Kim CH. Chemokines and their receptors in hematopoietic cell development and function. In Chemokines, Chemokine Receptors, and Disease. Edited by Lisa Schwiebert. Current Topics in Membranes (Elsevier. 2005), 55:115-142.

• Kim JR, Lim HW, Hillsamer P, Kim CH. Human CD57+ germinal center-T cells are the major helpers for GC-B cells and induce class switch recombination. BMC Immunology 2005, 6:3.

• Lim, HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells , J Immunol 2005 175: 4180-4183.

• Broxmeyer HE, Cooper S, Hangoc G, Kim CH. Stromal cell-derived factor-1/CXCL12 selectively counteracts inhibitory effects of myelosuppressive chemokines on hematopoietic progenitor cell proliferation in vitro. 2005. Stem Cells Dev. 14: 199-203.

• Kim CH. Migration and function of Foxp3+ regulatory T cells in hematolymphoid system (review). Exp. Hematol. 2006, 34:1033-40.

• Lim HW, Broxmeyer HE, Kim CH. Regulation of trafficking receptor expression in human forkhead box p3+ regulatory T cells. J Immunol. 2006 177(2):840-51.

• Kim CH. Regulation of humoral immunity by FoxP3+ regulatory T cells. Expert Review of Clinical Immunology, 2006. Vol. 2(6): 859-868

• Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311.

• Kim CH. Chemokines in Trafficking of Hematopoietic Stem and Progenitor Cells and Hematopoiesis (Chapter 8). In The Chemokine Receptors. Harrison and Lukacs. Ed. Humana Press, NJ, page 119-138; 2007.

• Kim CH. Molecular Targets of FoxP3(+) Regulatory T Cells.Mini Rev Med Chem. 2007 Nov;7(11):1136-43.

• Lim HW, Lee J, Hillsamer P, Kim CH.Human Th17 cells share major trafficking receptors with both polarized effector T cells and FOXP3+ regulatory T cells.J Immunol. 2008, 180:122-9.