Purdue University

Purdue University

School of Veterinary Medicine
Comparative Pathobiology

Suresh K. Mittal, D.V.M., Ph.D.


Interim Head
Professor of Comparative Pathobiology
University Faculty Scholar
Member of Purdue Cancer Center
Member of Bindley Bioscience Center
Department of Comparative Pathobiology
School of Veterinary Medicine
Purdue University
West Lafayette, IN 47907
Phone: 765-496-2894
FAX: 765-494-9830
Email: mittal@purdue.edu
Lab Website:
http://www.vet.purdue.edu/SureshMittal/

Image of Dr. Suresh Mittal

Education

Institution Field Degree Year
University of Cambridge, Cambridge, U.K. Virology Ph.D. 1989
Haryana Agricultural University, Hisar, India Microbiology M.S. 1984
Haryana Agricultural University, Hisar, India Veterinary Medicine D.V.M. 1982

Research Programs

    Human and nonhuman adenoviral vectors, recombinant vaccines, gene therapy, circumvention of adenoviral vector immunity and toxicity, targeted adenoviral vectors for cancer gene therapy, innate and adaptive immunity, immunization of elderly.

Awards and Honors

1985 Gold Medal for the best researcher of the University at Master's level
1985-1989 Cambridge Nehru Scholarship for PhD studies at the University of Cambridge
1992-1994 Saskatchewan Health Research Board Fellowship
1997 “FIRST Award” from National Institute of Health
1998-1999 Treasurer of Phi Zeta, The Honor Society of Veterinary Medicine
2003 Pfizer Award for Research Excellence
2006-2011 University Faculty Scholar, Purdue University
2007 Charles C. Shepard Award for the best peer-reviewed paper in the category of Prevention and Control, CDC
2008 Purdue University School of Veterinary Medicine Award for Research Excellence

Publications

Selected Publications

    1. Mittal, S. K., Middleton, D. M., Tikoo, S. K. and Babiuk, L. A. (1995). Pathogenesis and immunogenicity of bovine adenovirus type 3 in cotton rats (Sigmodon hispidus).  Virology 213:131-139.
    2. Breker-Klassen, M. M., Yoo, D., Mittal, S. K., Sorden, S. D., Haines, D. M. and Babiuk, L. A. (1995). Recombinant adenoviruses type 5 expressing bovine parainfluenza virus type 3 glycoproteins protect Sigmodon hispidus cotton rats from bovine parainfluenza virus type 3 infection.  J. Virol. 69:4308-4315.
    3. Mittal, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1995). Development of a bovine adenovirus-based expression vector. J. Gen. Virol. 76:93-102.
    4. Mittal, S. K., Bett, A. J., Prevec, L. and Graham, F L. (1995).  Foreign gene expression by human adenovirus type 5 based vectors studied using firefly luciferase and bacterial beta-galactosidase genes as reporters.  Virology 210:226-230.
    5. Mittal, S. K., Papp, Z., Tikoo, S. K., Baca-Estrada, M., Yoo, D., Benko, M. and Babiuk, L. A. (1996). Induction of systemic and mucosal immune responses in cotton rats immunized with human adenovirus type 5 recombinants expressing the full and secretory forms of bovine herpesvirus type 1 glycoprotein gD. Virology 222:299-309.
    6. Mittal, S. K., Middleton, D. M., Tikoo, S. K., Prevec, L., Graham, F. L. and Babiuk, L. A. (1996). Pathology and immunogenicity in the cotton rat (Sigmodon hispidus) model following infection with a bovine adenovirus type 3 recombinant virus expressing the firefly luciferase gene.  J. Gen. Virol. 77:1-9.
    7. Torres, J. M., Alonso, C., Ortega, A., Mittal, S. K., Graham, F. L. and Enjuanes, L. (1996). Tropism of human adenovirus 5 based vectors in swine and their ability to protect against transmissible gastroenteritis coronavirus. J. Virol. 70: 3770-3780.
    8. Papp, Z., Middleton, D. M., Mittal, S. K., Babiuk, L. A. and Baca-Estrada, M. E. (1997). Mucosal immunization with recombinant adenovirus vectors:  Induction of immunity and protection against respiratory bovine herpesvirus type 1 in the cotton rat model. J. Gen. Virol. 78:2933-2943.
    9. Mittal, S. K., Tikoo, S. K., van den Hurk, J. V., Breker-Klassen, M. M., Yoo, D. and Babiuk, L. A. (1998). Functional characterization of bovine parainfluenza virus type 3 hemaggutinin-neuraminidase and fusion proteins expressed by adenovirus recombinants. Intervirology 41:253-260.
    10. Aggarwal, N., HogenEsch, H., Guo, P., Adam North, Suckow, M. and Mittal, S. K. (1999). Biodegradable alginate microspheres as a delivery system for naked DNA. Can. J. Vet. Res. 63:148-152.
    11. van Olphen, A. L. and Mittal, S. K. (1999). Generation of infectious genome of bovine adenovirus type 3 by homologous recombination in bacteria. J. Virol. Methods 77:125-129.
    12. Mittal, S. K., Tikoo, S. K., van Donkersgoed, J., Godson, D. L. and Babiuk, L. A. (1999). Experimental inoculation of heifers with bovine adenovirus type 3. Can. J. Vet. Res. 63:153-156.
    13. Moffatt, S., HogenEsch, H., Hays, J. and Mittal, S. K. (2000). Circumvention of vector-specific antibody response by alternating use of human and non-human adenoviruses: implications in gene therapy. Virology 272:159-167.
    14. Mittal, S. K., Aggarwal, N., Sailaja, G., van Olphen, A. L., HogenEsch, H., North, A., Hays, J. and Moffatt, S. (2000). Immunization with DNA, adenovirus or both in biodegradable alginate microspheres: effect of route of inoculation on immune response. Vaccine 19:253-263.
    15. Aggarwal, N. and Mittal, S. K. (2000). Sequence analyses of porcine adenovirus type 3 E1 region, pIX, and pIVa2 genes. Intervirology 43:6-12.
    16. van Olphen, A. L., Tikoo, S. K. and Mittal, S. K. (2002). Characterization of bovine adenovirus type 3 early region 1 (E1) proteins and isolation of E1 expressing cell lines. Virology 295:108-118.
    17. van Olphen, A. L. and Mittal, S. K. (2002). Development and characterization of bovine x human hybrid cell lines that efficiently support the replication of both wild-type and E1-deleted bovine and human adenoviruses. J. Virol. 76: 5882-5892.
    18. Sailaja, G., HogenEsch, H., North, A., Hays, J. and Mittal, S. K. (2002). Encapsulation of recombinant adenovirus into alginate microspheres circumvents vector specific immune response. Gene Ther. 9:1722-1729.
    19. Bangari, D. S. and Mittal, S. K. (2004). Porcine adenoviral vectors evade preexisting humoral immunity to adenoviruses and efficiently infect both human and murine cells in culture.Virus Res. 105:127-36.
    20. Noblitt, L. W., Bangari, D. S., Shukla, S., Knapp, D. W., Mohammed, S., Kinch, M. S. and Mittal, S. K. (2004). Decreased tumorigenic potential of EphA2-overexpressing breast cancer cells following treatment with adenoviral vectors that express EphrinA1. Cancer Gene Ther. 11: 757766.
    21. Noblitt, L. W., Bangari, D. S., Shukla, S., Mohammed, S. and Mittal, S. K. (2005). Immunocompetent mouse model of breast cancer for preclinical testing of EphA2-targeted therapy. Cancer Gene Ther. 12:46-53.
    22. Bangari, D. S. and Mittal, S. K. (2005). Porcine adenovirus serotype 3 internalization is independent of CAR and avb3 or avb5 integrin.Virology 332:157-166.
    23. Bangari, D. S., Shukla, S. and Mittal, S. K. (2005). Comparative transduction efficiencies of human and nonhuman adenoviral vectors in human, murine, bovine, and porcine cells in culture. Biochem. Biophys. Res. Commun. 327:960-966.
    24. Bangari, D. S., Sharma, A. and Mittal, S. K. (2005). Bovine adenovirus type 3 internalization is independent of primary receptors of human adenovirus type 5 and porcine adenovirus type 3. Biochem. Biophys. Res. Commun. 331:1478-1484.
    25. Bangari, D. S. and Mittal, S. K. (2006). Development of nonhuman adenoviruses as vaccine vectors. Vaccine 24:849-862.
    26. Bangari, D. S. and Mittal, S. K.(2006). Current strategies and future directions for eluding adenoviral vector immunity. Curr. Gene Ther. 6:215-226.
    27. Hoelscher, M. A., Garg, S., Bangari, D. S., Belser, J., Lu, X., Stephenson, I., Bright, R. A., Katz, J. M., Mittal, S. K. and Sambhara, S. (2006). Development of adenoviral-vector-based pandemic influenza vaccine against antigenically distinct human H5N1 strains in mice. Lancet 367:475-81.
    28. Mittal, S. K. (2007). Respiratory viruses of animals causing disease in humans – Keystone Symposium. IDrugs 10:156-158.
    29. Hoelscher, M. A., Jayashankar, L., Garg, S. Veguilla, V., Lu, X., Singh, N., Katz, J. M., Mittal, S. K. and Sambhara S. (2007). New pre-pandemic influenza vaccines: An egg- and adjuvant-independent human adenoviral vector strategy induces long lasting protective immune responses in mice. Clin. Pharmacol. Ther. 82:665-671.
    30. Hoelscher, M. A., Singh, N., Garg, S., Jayashankar, L., Veguilla, V., Pandey, A., Matsuoka, Y., Katz, J. M., Donis, R., Mittal, S. K. and Sambhara, S. (2008). A broadly protective vaccine against globally dispersed clade 1 and clade 2 H5N1 influenza viruses. J. Infect. Dis. 197:1185-1188.
    31. Singh, N., Pandey, A., Jayashankar, L.. and Mittal, S. K. (2008). Bovine adenoviral vector-based H5N1 influenza vaccine overcomes exceptionally high levels of pre-existing immunity against human adenovirus. Mol. Ther. 16:965-971.
    32. Sharma, A., Bangari, D. S., Tandon, M., Pandey, A., HogenEsch, H. and Mittal, S. K. (2009). Comparative analysis of vector biodistribution, persistence and gene expression following intravenous delivery of bovine, porcine and human adenoviral vectors in a mouse model. Virology. 386(1):44-54.
    33. Sharma A, Li, X., Bangari, D. S. and Mittal, S. K. (2009). Adenovirus receptors and their implications in gene delivery. Virus Res. 143(2):184-94.
    34. Li, X., Bangari, D. S., Sharma, A. and Mittal, S. K. (2009) Bovine adenovrius serotype 3 utilizes sialic acid as a cellular receptor for virus entry. Virology. Jul 29. [Epub ahead of print]
    35. Bangari, D., Miller, M., Stevenson, G., Thacker, H., Sharma, A., and Mittal, S. K. (2009). Cutaneous and Systemic Poxviral Disease in Red (Tamiasciurus hudsonicus) and Gray (Sciurus carolinensis) Squirrels. Vet Pathol. 2009 Mar 9. [Epub ahead of print]

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