Nanomedicine in neuronal trauma and diseases

Nanoparticles have become a major field of exploration for medical applications. Based on their material properties, they can help to treat disease by delivering drugs to a specific area of the body to reduce side effects, diagnose diseases by enhancing detection methods (MRI or CAT scan), or a mixture of both. Regarding treatments, the use of nanoparticles can target diseased areas in the body and therefore enhance drug bioavailability and reduces dosing frequency. We are interested in employing various natural or synthetic polymers for the purpose of diagnosis and treatments in neuronal trauma and diseases. Specifically, we are interested in an effective drug carrier that can have the capability of carrying some effective compounds developed in this lab, such as potassium channel blockers and aldehyde scavengers, to be used in spinal cord and brain injury and chronic neurodegenerative diseases.

Selected publications related to the topic:

McKenzie, J.L., Cardona, B.E., Shi, R., and Webster, T.J. Cytocompatibility of carbon nanofibers for use as a neural biomaterial, Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 3: 2119-2120, 2002.

McKenzie, J.L., Waid, M.C., Shi, R., Webster, J. Cytocompatibility of Carbon Nanofiber Materials for Neural Applications. Materials Research Society Symposium - Proceedings, 774: 17-22, 2003.
McKenzie, J.L., Waid, M.C., Shi, R. and Webster, T.J. Decreased functions of astrocytes on carbon nanofiber materials. Biomaterials 25:1309-1317, 2004.

McKenzie, J.L., Shi, R., Kalkhoran, N.M., Sambito, M.A., Webster, T.J. Analysis of carbon nanofibers and porous silicon for neural applications. Proceedings of the IASTED International Conference on Biomedical Engineering, 557-560, 2004.

McKenzie, J.L., Shi, R., Webster, T.J. Increased neurite extension for neurons cultured on carbon nanofiber compacts. Transactions - 7th World Biomaterials Congress, 284, 2004.

McKenzie, J.L., Shi, R., Kalkhoran, N.M., Sambito, M.A., Webster, T.J. In vitro analysis of carbon nanofiber and mesoscale porous silicon materials with nanoscale roughness for neural applications. Materials Research Society Symposium Proceedings, EXS (1), 311-316, 2004.

McKenzie, J.L., Shi, R., Webster, T.J., Material design for neural applications using carbon nanofibers. Medical Device Materials II. Proceedings of the Materials and Processes for Medical Devices Conference 2004, 159-164, 2005.

Cho, Y., Shi, R., Borgens, R., and Ivanisevic, A. The Functionalized Mesoporous Silica Nanoparticles (MSNs) Based Drug Delivery System to Rescue Acrolein-Mediated Cell Death. Nanomedicine. 3: 507-519. 2008

Cho, Y., Shi, R., Borgens, R and Ivanisevic, A. Repairing the damaged spinal cord and brain with nanomedicine. Small. 4: 1676-1681.2008.

Cho, Y., Shi, R., Ivanisevic, A., and Borgens. A mesoporous silica nanosphere-based drug delivery system using electrically condcting polymer. Nanotechnology. 20: 275102. 2009.

Cho*, Y., Shi*, R., and Borgens, R. Chitosan nanoparticle-based neuronal membrane sealing and neuroprotection following acrolein-induced cell injury. Journal of Biological Engineering. 4:2, 2010. (open access: http://www.jbioleng.org/content/4/1/2). *: equal contribution.
Cho, Y., Shi, R., Ivanisevic, A., and Borgens, R. Functional silica nanoparticle-mediated neuronal membrane sealing following traumatic spinal cord injury. J. Neurosci. Res. 88, 1433-1444. 2010.

Cho, Y., Shi, R., and Borgens, R. Chiotosan produces potent Neuroprotection and physiological recovery following traumatic spinal cord injury. Journal of Experimental Biology. 213, 1513-1520. 2010.