Mechanisms and treatments of neurodegenerative diseases - Multiple sclerosis and Parkinson's disease.
Recently, Dr. Shi and colleagues have also established animal models for Parkinson's disease (rat, 6-OHDA) and multiple sclerosis (mice, EAE). They have gathered a significant amount of evidence which suggests that neurodegenerative diseases and neuronal trauma may share similar mechanisms in cellular degeneration. Specifically, oxidative stress appears to be the key element in mediating cell death in all these conditions. They are currently working on revealing the molecular mechanisms of cellular damage. Effort has been taking to establish effective pharmaceutical intervention aiming to prevent, delay, or even reverse the pathology of neurotrauma and neurodegenerative diseases.
Selected publications related to the topic:
Shi, Y., Sun, W., McBride, J., Cheng, J. and Shi, R. Acrolein induces myelin damage in mammalian spinal cord. J. Neurochem. 117: 554-564, 2011.
Leung, G., Sun , W., Zheng, L., Brookes, S, Tully, M., and Shi, R. Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in EAE mouse. Neuroscience. 173: 150-155, 2011.
Leung, G., Sun , W., Brookes, S, Smith, D., Shi, R. Potassium channel blocker, 4-Aminopyridine-3-Methanol, restores axonal conduction in spinal cord of an animal model of multiple sclerosis. Experimental Neurology 227:232-235, 2011.