Few studies have investigated possible adverse effects of frequent vaccination of dogs. We are currently investigating the effects of vaccination on the immune and endocrine system in Beagles. Our research group has demonstrated that vaccinated Beagles develop autoantibodies to several highly conserved antigens after vaccination. This study is continuing to determine the clinical significance of these antibodies. We also are investigating the effect of vaccination on autoantibodies in adult pet dogs.

Thyroiditis is a well recognized problem in Beagles which is believed to be a heritable trait. We are currently studying the natural history of this disease in a group of 20 healthy female Beagles.

Other studies in progress or recently completed, include investigation of the canine TSH assay for the diagnosis of canine hypothyroidism and investigation of the effect of potassium bromide on thyroid function and morphology in dogs.

Feline hyperthyroidism is the most common endocrine disease of geriatric cats and the prevalence of the disease has significantly increased since the first reports of feline hyperthyroidism in the 1970s. Currently Purdue treats more than 80 cats a year for this problem with radioactive iodine (please see the hospital web page for details of this clinical program (http://www.vet.purdue.edu/depts/vcs/scottmon/catiodine3.html). Research projects ongoing in association with this clinical program include studies of the epidemiology of feline hyperthyroidism and studies investigating the treatment of feline thyroid carcinoma with high dose radioactive iodine.

Yu M-D, Peck GE, Scott-Moncrieff JC, Blevins WE, Shaw SM. The effect of formulation on radioiodide thyroid uptake in the hyperthyroid cat. Drug Development and Industrial Pharmacy 1999;25:565-570.

HogenEsch H, Azcona-Olivera JI, Scott-Moncrieff JC, Snyder PW, Glickman LT. Vaccine-induced autoimmunity in the dog. Advances in veterinary medicine: Veterinary vaccines and diagnostics 1999;41:733-745.

Scott-Moncrieff JC, Nelson RW. Change in serum canine thyroid stimulating hormone concentrations in response to administration of thyrotropin releasing hormone in healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease. J Am Vet Med Assoc 1998:213:1435-1438.

Bruner JM, Scott-Moncrieff JC, Williams DA. Effect of time of sample collection on serum thyroid stimulating hormone concentrations in euthyroid and hypothyroid dogs. J Am Vet Med Assoc 1998;212:1572-1575.

Scott-Moncrieff JC, Nelson RW, Bruner JM, Williams DA. Serum thyrotropin concentrations in healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease. J Am Vet Med Assoc 1998;212:387-391.

Scott-Moncrieff JC. Serum canine thyrotropin concentrations in experimental and spontaneous hypothyroidism. Canine Practice 1997;22:41-42.

Williams DA, Scott-Moncrieff JC, Bruner J, Sustarsic D, Panosian-Sahakian N, Unver E, El Shami AS. Validation of an immunoassay for canine thyroid-stimulating hormone (cTSH) and changes in serum concentrations following induction of hypothyroidism in dogs. J Am Vet Med Assoc 1996;209:1730-1732.

Guptill C, Scott-Moncrieff JC, Janovitz EJ, Blevins WE. Response to high-dose radioactive iodine administration in cats with thyroid carcinoma that had previously undergone surgery. J Am Vet Med Assoc 1995;207:1055-1058.

Miller AB, Nelson RW, Scott-Moncrieff JC, Neal L, Bottoms GD. Serial thyroid concentrations in healthy euthyroid dogs, dogs with hypothyroidism and euthyroid dogs with atopic dermatitis. Br Vet J 1992;148:451-458.

Date Last Modified: August 1999
Author: Clerical Services Group
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