Scott Crist, PhD

Department of Comparative Pathobiology

Research Assistant Professor

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.494.5674
Email: scrist@purdue.edu

Education

1997 - PhD | University of Kentucky
1990 - BS | University of Iowa

Experience

2007 - | Assistant Research Professor, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana.
2007 - | Assistant Research Professor, Department of Comparative Pathobiology, School of Veterinary Medicine, Purdue University, West Lafayette, Indiana.
2004 - 2007 | Associate Research Scientist, Department of Urology, University of Iowa, Iowa City, Iowa
2004 - | Associate Research Scientist, Principle Investigator of a NIH-funded project Department of Urology, University of Iowa, Iowa City, Iowa
2003 - 2004 | Research Investigator, (Supervisor: Dr. Timothy Ratliff) Department of Urology, University of Iowa, Iowa City, Iowa
2002 - 2004 | Research Investigator, Department of Urology, University of Iowa. Iowa City, Iowa.
2000 - 2000 | Discussion Group proctor, Medical Immunology College of Medicine, University of Iowa, Iowa City, Iowa
1999 - 1999 | Discussion Group proctor, Medical Immunology, College of Medicine, University of Iowa, Iowa City, Iowa
1999 - 2002 | Research Fellow, Department of Urology, University of Iowa, Iowa City, Iowa Advisor: Tim Ratliff, Ph.D.
1999 - 2003 | Research Fellow, (Supervisor: Dr. Timothy Ratliff) Department of Urology, University of Iowa, Iowa City, Iowa
1997 - 1999 | Research Fellow, (Supervisor: Dr. William See) Department of Urology, University of Iowa, Iowa City, Iowa
1997 - 1999 | Research Fellow, Department of Urology, University of Iowa. Advisor: William See, M.D.
1995 - 1995 | Teaching Assistant as a Doctoral Candidate in the Department of Microbiology and Immunology, University of Kentucky. Coordinator: Robert Perry, Ph.D. Medical Microbiology. Assisted in the instruction (laboratory and lecture) of 2nd year medical students i
1992 - 1997 | Teaching/Research Assistant, Doctoral candidate, Department of Microbiology and Immunology, University of Kentucky, Lexington, Kentucky
1992 - 1997 | Research Assistant as a Doctoral Candidate in the Department of Microbiology and Immunology, University of Kentucky. Advisor: Vivek Rangnekar, Ph.D.
1989 - 1992 | Laboratory Technician, Department of Urology, University of Iowa Hospitals & Clinics, Iowa City, Iowa. Supervisor: William See, MD.
1989 - 1992 | Laboratory Technician, Department of Urology, University of Iowa Hospitals and Clinics, Iowa City, Iowa
1988 - 1989 | Undergraduate work-study, University of Iowa, Department of Microbiology, Supervisor: David Lubaroff, Ph.D. and Department of Urology, Supervisor: William See, MD
1986 - 1989 | Floor Nurse, part-time, Departments of Orthopedics, Dermatology, Urology, and Neurosurgery. University of Iowa Hospitals and Clinics, Iowa City, Iowa
1986 - 1988 | Undergraduate work-study, University of Iowa, Department of Microbiology, Supervisor: Thomas Feldbush, Ph.D.
1985 - 1986 | Private Tutor, Kirkwood Community College, Department of Math and Sciences

Selected Publications

Crist SA, Sprague DB, and Timothy L. Ratliff. Retinoids are potent inducers of CD154 in megakaryocytes. (In preparation)
Crist SA, Sprague DB, and Timothy L. Ratliff. CD154 expression in megakaryocytes is dependent on a functional Ets-1 element proximal to the transcription start site. (In preparation)
Crist SA, Sprague DB, and Timothy L. Ratliff. CD154 Expression and Regulation in Megakaryocytes and Platelets. (Resubmitted as a revived manuscript to Blood Journal)
Scott A. Crist, Bennett D. Elzey, Jeffery Stakk, Haley W. Sinn, Steven Lentz, and Timothy L. Ratliff. Regulation of Fas ligand expression in megakaryocytes. (Submitted)
Crist SA, Sprague, DB, Griffith TS, Staack JB, Ratliff TL. Transcriptional regulation of TNF-related apoptosis-inducing ligand (TRAIL) in megakaryocytes. (Resubmitted to Exp Hematol as a revised manuscript).
Crist SA, Elzey BD, Ludwig AT, Griffith TS, Staack JB, Lentz SR, Ratliff TL. Expression of TNFrelated apoptosis-inducing ligand (TRAIL) in megakaryocytes and platelets. Exp Hematol. 2004 Nov;32(11):1073-81.
Crist SA, Griffith TS, Ratliff TL. Structure/function analysis of the murine CD95L promoter reveals the identification of a novel transcriptional repressor and functional CD28 response element. J Biol Chem. 2003 Sep 19;278(38):35950-8.
Siemens DR, Crist S, Austin JC, Tartaglia J, Ratliff TL. Comparison of viral vectors: gene transfer efficiency and tissue specificity in a bladder cancer model. J Urol. 2003 Sep;170(3):979-84.
Chen F. H., Crist, S. A., Zhang, G. J., Iwamoto, Y. and W. A. See. Interleukin-6 production by human bladder tumor cell lines is up-regulated by bacillus Calmette-Guerin through nuclear factor-kappaB and Ap-1 via an immediate early pathway. J Urol. 168:78
Zhang, Guang-Jian, Crist, Scott A., McKerrow, Amy, Ladehoff, David, and William A. See. Autocrine Interleukin-6 Production by Human Transitional Carcinoma Cell Lines Upregulate Expression of the a5b1 Fibronectin Receptor. J Urol. 163:1553-9, 2000
Muthukkumar, S., Sells, S.F., Crist, S.A., Rangnekar, V.M. Interleukin-1 induces growth arrest by hypophosphorylation of the retinoblastoma gene product, Rb. J. Biol. Chem. 271:5733-5740, 1996
Sells, S.F., Muthukkumar, S., Sukhatme, V.P., Crist, S.A., Rangnekar, V.M. The zinc finger transcription factor EGR-1 impedes interleukin-1 inducible tumor growth arrest. Mol. Cell. Biol. 15:682- 692, 1995
Sells, S.F., Wood, D.P., Jr., Joshi-Barve, S.S., Muthukkumar, S., Jacob, R.J., Crist, S.A., Humphreys, S., Rangnekar, V.M. Commonality of the Gene Programs Induced by Effectors of Apoptosis in Androgendependent and -independent Prostate Cells. Cell Growth
See, W.A., Yong, X., Crist, S.A., Hedicen, S. Diversity and modulation of plasminogen activator for activity in human transitional carcinoma cell lines. J. Urol..151:1691-1696, 1994.
See, W.A., Rohlf, D.P., Crist, S.A. In vitro particulate adherence to fibronectin: correlation with in vivo particulate adherence to sites of bladder injury. J. Urol. 147:1416-1423. 1993
See, W.A., Crist, S.A., Williams, R.D. Single-dose preoperative systemic cyclophosphamide for the prevention of bladder tumor implantation in F-344 rats: site of drug activity. Cancer Res. 51:1378-1383,1991.
See, W.A., Crist, S.A., Boileau, M.A., Williams, R.D. Single-dose preoperative systemic cyclophosphamide for the prevention of bladder tumor implantation in F-344 rats. Cancer Res. 51:1373-1377, 1991.

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