Purdue Histology & Phenotyping Laboratory - PHPL
Purdue University, through the College of Veterinary Medicine, offers histology expertise for investigators involved in biomedical research through the Purdue Histology & Phenotyping Laboratory (PHPL). The PHPL is comprised of two units. One unit is a full service histology laboratory that not only provides routine procedures, but also functions to collaborate with investigators in the development of new techniques and in the characterization of animal models (e.g. phenotyping of genetically altered mice). The other unit is a bone and articulation laboratory that provides decalcified and non-decalcified techniques, and prosthesis sectioning. This unit also functions to collaborate with investigators in the development of new techniques for biomaterials with application to biomedical research. The PHPL is directed by Dr. Paul W. Snyder who oversees the units and provides expertise in the development, validation and interpretation of the studies performed in these laboratories.
Phenotyping service for genetically altered mice includes whole body and individual organ weights, blood collection for clinical chemistry testing and complete blood counts, extensive gross examination and histological examination. This evaluation provides the investigator with a baseline evaluation to be used in determining if they have a phenotype that justifies an extended characterization that may include other forms of tissue evaluations and/or imaging.
Ms. Donna Brooks