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Prestigious Journal's Cover Features PVM Scholar's Breakthrough Research

March 22, 2013

Professor of Immunology Chang Kim in Purdue Veterinary Medicine’s Department of Comparative Pathobiology recently published a breakthrough discovery on the regulation of T cell migration in the intestine. The article was published in the March 11 issue of the Journal of Experimental Medicine and was featured on the publication’s cover. The intestine contains a large population of T cells that play central roles in fighting pathogens in the intestine. Abnormal function of T cells also contributes to inflammatory bowel disease and Crohn’s disease. T cells must express trafficking receptors required for their migration to the intestine. Dr. Kim identified the critical role of the transcription factor BATF in the expression of these trafficking receptors specific for the intestine. This discovery opens possible paths for the development of new drugs to modify the migration of T cells to the intestine. This work was conducted in collaboration with Purdue Professor of Biological Sciences Elizabeth Taparowsky. To view the article, click here

Writer: Kevin Doerr, pvmnews@purdue.edu