Purdue University

Canine Bladder CancerCanine Bladder Cancer (Transitional cell carcinoma)

• Investigational IV chemotherapy—a new chemotherapy protocol is being investigated for efficacy and safety.  Free medication available.  Owner must pay evaluation and administration costs.
• Metronomic (low dose, oral) chemotherapy—an investigational new approach to delivery of chemotherapy.
• Folate-targeted therapy—see description below

In conjunction with the NIH, we are studying the DNA of dogs with TCC with the goal of discovering factors causing genetic predisposition for this disease.  A very small amount of blood is requested from Scottish Terriers and West Highland White Terriers over 5 years old and have confirmed (via biopsy)TCC. 

• Dog Genome Project at the National Human Genome Research Institute  - http://research.nhgri.nih.gov/dog_genome

Tissue samples at the time of euthanasia of any dog or cat with TCC would be valuable.  Snap frozen or formalin-fixed tissues of the urinary bladder tumor, regional lymph nodes, liver, and any other suspected site of tumor spread are requested.

• Varying degrees of funding available.
• Further information at www.vet.purdue.edu/pcop, bonney@purdue.edu, or (765)494-1130.

Folate-Targeted TherapyBecause certain cancers in dogs and humans take up the vitamin, folate, Purdue researchers are investigating a folate/chemotherapy conjugate as a way of selectively delivering therapy to the tumor.  

• Partial funding available. 
• Dr. Knapp/Patty Bonney at (765)494-1130.            

Malignant Lymphoma

Dogs with multicentric lymphoma are being recruited to assess the extent to which prednisone induces chemotherapy resistance and affects remission duration.

• Influence of Prednisone on Remission and P-Glycoprotein Expression in Dogs with Lymphoma
• Dr. Mike Childress/Ms. Sarah Lahrman, RVT, at (765) 494-1107

Canine OsteosarcomaA new treatment protocol is being evaluated post amputation with a diagnosis of osteosarcoma.

• Dr. Diane Schrempp/Patty Bonney at (765) 494-1130

 Any Malignancy

Anti-angiogenic Therapy –Dogs with any malignancy will be treated with an oral anti-angiogenic agent.

• Dr. Debbie Knapp/Patty Bonney, RVT  at (765) 494-1130
  

Blood and Tissue Samples Needed In a continuing effort to learn more about the causes of canine bladder cancer (TCC) and how the disease forms and progresses, our research group is conducting studies on blood samples from dogs with TCC and blood samples from dogs of similar age and breed who do not have TCC.  Studies are also being...

• Dr. Debbie Knapp/Patty Bonney, RVT  at (765) 494-1130

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