Purdue University

Canine Bladder Cancer Treatment of Canine Bladder Cancer (Transitional cell carcinoma, "TCC")

• Metronomic (low dose, oral) chemotherapy—an investigational new approach to delivery of chemotherapy.

A new chemotherapy protocol is being evaluated for dogs with transitional cell carcinoma of the urinary bladder.  The study will compare the chemotherapy by itself vs. that chemotherapy combined with an NSAID.  A diagnosis via tissue biopsy is required.

• The chemotherapy will be provided at no cost to the owner, although the owner will be responsible for some costs.
• For further information, please call (765) 494-1130 and speak with Dr. Knapp, Lindsey Fourez, or Patty Bonney.

Imaging Bladder Cancer

• A new ultrasound imaging system is being evaluated to more accurately detect and measure bladder tumors.

Causes of Bladder Cancer

In conjunction with the Ostrander Lab at NIH, we are studying the DNA of dogs with TCC with the goal of discovering factors causing genetic predisposition for this disease.  A very small amount of blood is requested from Scottish Terriers, West Highland White Terriers and Shetland Sheepdogs over 5 years old and have confirmed (via biopsy)TCC. 

• Dog Genome Project at the National Human Genome Research Institute  - http://research.nhgri.nih.gov/dog_genome
  

Learning More About TCC

Tissue samples at the time of euthanasia of any dog or cat with TCC would be valuable.  Snap frozen or formalin-fixed tissues of the urinary bladder tumor, regional lymph nodes, liver, and any other suspected site of tumor spread are requested.

• Varying degrees of funding available.
• Further information at www.vet.purdue.edu/pcop, bonney@purdue.edu, or (765) 494-1130.

Folate-Targeted Therapy

Because certain cancers in dogs and humans take up the vitamin, folate, Purdue researchers are investigating a folate/chemotherapy conjugate as a way of selectively delivering therapy to the tumor.  

• Partial funding available. 
• Dr. Knapp/Patty Bonney at (765) 494-1130.     

        Malignant Lymphoma

Influence of Prednisone on Remission and P-glycoprotein expression in Dogs with Lymphoma

• Dogs with multicentric lymphoma are being recruited to assess the extent to which prednisone induces chemotherapy resistance and affects remission duration.
• For questions contact Dr. Mike Childress/Ms. Sarah Lahrman, RVT, at (765) 494-1107

Canine Osteosarcoma A new treatment protocol is being evaluated post amputation with a diagnosis of osteosarcoma.

• Dr. Diane Schrempp/Patty Bonney at (765) 494-1130

Blood and Tissue Samples Needed In a continuing effort to learn more about the causes of canine bladder cancer (TCC) and how the disease forms and progresses, our research group is conducting studies on blood samples from dogs with TCC and blood samples from dogs of similar age and breed who do not have TCC.  Studies are also being...

• Dr. Debbie Knapp/Patty Bonney, RVT  at (765) 494-1130

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