Chang H. Kim, PhD
Department of Comparative Pathobiology
1998 - PhD | Indiana University School of Medicine
1992 - MS | Korea Advanced Institute of Science and Technology
1990 - BS | Korea Advanced Institute of Science and Technology
2010 - | Professor of Immunology, Department of Comparative Pathobiology, Purdue University
2006 - 2010 | Associate Professor of Immunology, Department of Comparative Pathobiology, Purdue University
2004 - | Member, Purdue University Life Science Program (Molecular Signaling and Cancer Biology; Microbial Pathogenesis)
2003 - | Adjunct Professor, Indiana University School of Medicine
2002 - | Affiliate Member, Bindley Bioscience Center
2002 - | Member, Purdue Cancer Center
2002 - | Member, Biochemistry and Molecular Biology Program, Purdue University
2002 - 2006 | Assistant Professor of Immunology, Department of Veterinary Pathobiology, Purdue University
1999 - 2002 | Postdoctoral Fellow, Stanford University School of Medicine
1998 - 1999 | Postdoctoral Fellow, Indiana University School of Medicine
1995 - 1998 | Instructor, Microbiology and Immunology, Indiana University School of Medicine
1992 - 1995 | Research Scientist, LG Chem. LTD., S. Korea
Kim CH, Pelus LM, White JR, and Broxmeyer HE. Differential chemotactic behavior of developing T cells in response to thymic chemokines. Published as a rapid communication article. 1998, Blood, 91:4434-4443.
Kim CH, Qu C, Hangoc G, Cooper S, Feng G-S, and Broxmeyer HE, Abnormal chemokine induced responses of immature and mature hematopoietic cells from motheaten mice: Implication of the protein tyrosine phosphatase SHP-1 in chemokine responses, 1999, J. Exp. Med., 190:681-690.
Kim CH, Hangoc G, Cooper S, Helgason CD, Yew S, Humphries RK, Krystal G, and Broxmeyer HE, Altered responsiveness to chemokines due to targeted disruption of SHIP. 1999, J. Clin. Invest. 104:1751.
Kim CH, Kunkel, EJ, Boisvert J, Johnston B, Campbell JJ, Genovese MC, Greenberg HB, and Butcher EC. Bonzo/CXCR6 defines polarized Type 1 memory/effector T cell subsets with extra-lymphoid tissue homing potential. 2001, J. Clin. Invest.107: 595.
Kim CH, Rott LS, Clark-Lewis I, Campbell DJ, Wu L, Butcher EC. Subspecialization of CXCR5+ T cells: B helper activity is focused in a germinal center-localized subset of CXCR5+ T cells. 2001, J. Exp. Med. 193:1373.
Kim CH, Rott LS, Kunkel EJ, Genovese M, Andrew DP, Wu L, and Butcher EC. Rules of chemokine receptor association with T cell polarization in vivo. 2001, J. Clin. Invest, 108:1331.
Campbell DJ, Kim CH and Butcher EC, Separable populations of effector CD4+ T cells mediate B cell help and tissue inflammation. 2001, Nature Immunology, 9:876-881
Lim HW, Hillsamer P, Kim CH. Regulatory T cells acquire migratory capacity to follicles upon T cell activation and suppress GC-T helper cell-driven B cell responses. 2004. J Clin Invest. 114:1640-1649. PMID: 15578096; PubMed Central PMCID: PMC529283.
Lim HW, Hillsamer P, Banham AH, and Kim CH, Cutting Edge: Direct Suppression of B Cells by CD4+CD25+ Regulatory T Cells. J Immunol 2005 175: 4180-4183. PMID: 16177055.
Lim HW, Broxmeyeweb_pvmGenDBdevr HE, Kim CH. Regulation of trafficking receptor expression in human FOXP3+ regulatory T cells. J Immunol 2006 177:840-51. PMID: 16818738.
Lee JH, Kang SG, Kim CH. FoxP3+ T cells undergo conventional first switch to lymphoid tissue homing receptors in thymus but accelerated second switch to non-lymphoid tissue homing receptors in secondary lymphoid tissues. 2007, J Immunol 2007 178: 301-311. PMID: 17182567.
Kang SG, Piniecki RJ, Lim HW, HogenEsch H, Braun SE, Wiebke E, Matsumoto S, Kim CH. Identification of a chemokine network that recruits FoxP3+ regulatory T cells to inflamed intestine. Gastroenterology, 2007, 132, 966-981. PMID: 17324406.
Kang SG, Lim HW, Andrisani OM, Broxmeyer HE, and Kim CH. Vitamin A Metabolites Induce Gut Homing FoxP3+ Regulatory T cells. J Immunol, 2007. 179: 3724-3733. PMID: 17785809.
Lim HW, Lee, JH, Hillsamer P, Kim CH. Human Th17 cells share major trafficking receptors with both polarized effector T cells and FoxP3+ regulatory T cells. J Immunol., 2008, 180:122-9. PMID: 18097011.
Wang, C.W., S.G. Kang, J.H. Lee, and Kim CH. The roles of CCR6 in migration of Th17 cells and regulation of effector T cell balance in the gut. Mucosal Immunology, 2009, 2:173-83. PMID: 19129757
Kang SG, Wang C, Matsumoto S, Kim CH. High and low vitamin A therapies induce distinct FoxP3+ T-cell subsets and effectively control intestinal inflammation. Gastroenterology. 2009 Oct;137(4):1391-402.
Betz BC, Jordan-Williams KL, Wang C, Kang SG, Liao J, Logan MR, Kim CH, Taparowsky EJ. Batf coordinates multiple aspects of B and T cell function required for normal antibody responses. J Exp Med. 2010 May 10;207(5):933-42. PMID: 20421391
Wang C, Kang SG, HogenEsch H, Love PE, Kim CH. Retinoic acid determines the precise tissue tropism of inflammatory Th17 cells in the intestine. J Immunol. 2010 May 15;184(10):5519-26. PMID: 20400707
Kang SG, Park J, Cho JY, Ulrich B, Kim CH. Complementary roles of retinoic acid and TGF-?1 in coordinated expression of mucosal integrins by T cells. Mucosal Immunol. 2011 Jan;4(1):66-82.. PMID: 20664575
Lee JH, Ulrich B, Cho J, Park J, Kim CH. Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. PMID: 21768398
Lee JH, Lydon J, Kim CH. Progesterone suppresses the mTOR pathway and promotes generation of induced regulatory T cells with increased stability. Eur J Immunol. 2012 Jun 28. doi: 10.1002/eji.201142317.