Neuroscience and Biomedical Engineering
Department of Basic Medical Sciences
Center for Paralysis Research
School of Veterinary Medicine
Weldon School of Biomedical Engineering
West Lafayette, IN 47907-1244
Tel: (765) 496-3018
Fax: (765) 494-7605
Riyi Shi is a medical scientist specializing in uncovering the mechanisms of central nervous system trauma and diseases and instituting new treatments through innovative experimentation and pioneering new strategies in the field. His research contributions includes originating the use of double sucrose gap technique for recording action potential conduction, establishing the methods of neuronal membrane resealing by polyethelyne glycol (PEG), and identifying acrolein as a key pathological factor in spinal cord injury and multiple sclerosis. His research interests also include using nanotechnology to improve drug delivery to nervous tissue and incorporating biomedical engineering principles to enhance neuronal repair and diagnosis. This includes designing innovative scaffolds to enhance neuronal regeneration and using bioadhesives for neuronal tissue repair.
Researchers led by Dr. Riyi Shi have received $1.5 million to study the role of a toxin thought to worsen the severity of spinal cord injuries and to learn whether reducing its concentration in the days following trauma also decreases damage that can lead to paralysis.
"Spinal cord injury is a devastating medical condition with no effective treatments despite decades of research efforts," said Riyi Shi (pronounced Ree Shee), lead researcher on the project and a professor in Purdue University's Department of Basic Medical Sciences, School of Veterinary Medicine, Center for Paralysis Research and Weldon School of Biomedical Engineering.