Shankar Thangamani, DVM, PhD

Assistant Professor of Microbiology

Department of Comparative Pathobiology

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.494.0763
Email: sthangam@purdue.edu

Thangamani Lab

Education

2016 - PhD | Purdue University
2009 - DVM | Madras Veterinary College, India

Areas of Interest

Colonization resistance mechanisms to enteric fungal and bacterial pathogens
Metabolite/Microbiome based therapeutics
Small molecule inhibitors against fungal/bacterial pathogens

Experience

2021 - Present | Assistant Professor of Microbiology, Purdue University, West Lafayette, IN
2017 - 2021 | Assistant Professor of Microbiology, Midwestern University, College of Veterinary Medicine, Glendale, AZ
2010 - 2016 | Research Assistant, Department of Comparative Pathobiology, Purdue University, West Lafayette, IN

Selected Publications

– Saif Hameed, Sandeep Hans, Shweta Singh, Ruby Dhiman, Ross Monasky, Ramendra Pati Pandey, Shankar Thangamani, and Zeeshan Fatima. Revisiting the Vital Drivers and Mechanisms of β-Glucan Masking in Human Fungal Pathogen, Candida albicans. Pathogens (* Corresponding authors)

– Saif Hameed, Sandeep Hans, Ross Monasky, Shankar Thangamani*, Zeeshan Fatima*. Understanding Human Microbiota Offers Novel and Promising Therapeutic Options against Candida Infections. Pathogens (* Corresponding authors)

– Ross Monasky, Sonia Villa, Thangamani S*. An Ex vivo Assay to Study Candida albicans Hyphal Morphogenesis in the Gastrointestinal Tract. Journal of Visualized Experiments (JoVE) (* Corresponding author)

– Sonia Villa, Mohammad Hamideh, Anthony Weinstock, Mohammad N Qasim, Tony R Hazbun, Adnane Sellam, Aaron D Hernday, Thangamani S*. Transcriptional control of hyphal morphogenesis in Candida albicans. FEMS Yeast Research. (* Corresponding author

– Lawson S, Arumugam N*, Abdulrahman I. Almansour, Kumar R, Thangamani S*. Dispiropyrrolidine Tethered Piperidone Heterocyclic Hybrids with Broad-Spectrum Antifungal Activity Against Candida Albicans and Cryptococcus Neoformans. Bioorganic Chemistry (* Corresponding authors)

– Gutierrez D, Weinstock A, Antharam VC, Gu H, Jasbi P, Shi X, Dirks B, Krajmalnik-Brown R, Maldonado J, Guinan J, Thangamani S*. Antibiotic-induced gut metabolome and microbiome alterations increase the susceptibility to Candida albicans colonization in the gastrointestinal tract. FEMS Microbiology Ecology (* Corresponding author)

– Weinstock A, Arumugam N*, Abdulrahman I. Almansour, Kumar R, Thangamani S*. Discovery of diazahexa/hepta cyclic cage-like systems compounds with broad-spectrum antifungal activity against Candida and Cryptococcus species. RSC Advances (* Corresponding authors)

– Guinan J, Wang S, Hazbun TR, Yadav H, Thangamani S*. Antibiotic-induced decreases in the levels of microbial-derived short-chain fatty acids correlate with increased gastrointestinal colonization of Candida albicans. Scientific Reports (* Corresponding author)

– Bolous M, Arumugam N*, Almansour AI, Suresh Kumar R, Maruoka K, Antharam VC, Thangamani S*. Broad-spectrum antifungal activity of spirooxindolo-pyrrolidine tethered indole/imidazole hybrid heterocycles against fungal pathogens. Bioorganic and Medicinal Chemistry Letters (* Corresponding authors)

– Villa P, Arumugam N*, Almansour AI, Suresh Kumar R, Mahalingam SM, Maruoka K, Thangamani S*. Benzimidazole tethered pyrrolo[3,4-b]quinoline with broad-spectrum activity against fungal pathogens. Bioorganic and Medicinal Chemistry Letters (* Corresponding authors)

– Guinan J, Thangamani S*. Antibiotic-induced alterations in taurocholic acid levels promote gastrointestinal colonization of Candida albicans. FEMS Microbiology Letters (* Corresponding author)

– Guinan J, Villa P, Thangamani S*. Secondary bile acids inhibit the growth and morphogenesis of Candida albicans. Pathogens and Disease (* Corresponding author)

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