Bennett D. Elzey, PhD

Department of Comparative Pathobiology

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Phone: 765.496.0212
Email: belzey@purdue.edu

Purdue Institute of Inflammation, Immunology and Infectious Diseases

Education

1999 - PhD | University of Iowa
1990 - BS | Iowa State University

Areas of Interest

The role of myeloid-derived suppressor cells in cancer progression
The role of platelets in generating adaptive immune responses
Cancer biology

Experience

2007 - | Assistant Research Professor, Purdue University
2006 - 2007 | Faculty Associate, University of Iowa
2002 - 2002 | Teaching Assistant, University of Iowa - Medical Immunology
2001 - 2006 | Postdoctoral Research Fellow, University of Iowa
1999 - 2001 | Postdoctoral Scientist, University of Iowa
1997 - 1998 | Graduate Teaching Assistant, University of Iowa - Microbiology for Health Sciences
1992 - 1993 | Laboratory Supervisor, Cargill, Inc., Eddyville, IA
1990 - 1992 | Quality Control Scientist, Cargill, Inc., Eddyville, IA

Selected Publications

– Kim A, Zhou J, Samaddar S, Song SH, Elzey BD, Thompson DH, Ziaie B. An Implantable Ultrasonically-Powered Micro-Light-Source (µLight) for Photodynamic Therapy. Sci Rep. 2019 9:1395 PMID: 30718792

– Naganna N, Opoku-Temeng C, Choi EY, Larocque E, Chang ET, Carter-Cooper BA, Wang M, Torregrosa-Allen SE, Elzey BD, Lapidus RG, Sintim HO. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice. EBioMedicine. 2019 Jan 24. doi: 10.1016/j.ebiom.2019.01.012. [Epub ahead of print] PMID: 30686755

– Orillion A, Damayanti NP, Shen L, Adelaiye-Ogala R, Affronti H, Elbanna M, Chintala S, Ciesielski M, Fontana L, Kao C, Elzey BD, Ratliff TL, Nelson DE, Smiraglia D, Abrams SI, Pili R. Dietary Protein Restriction Reprograms Tumor-Associated Macrophages and Enhances Immunotherapy. Clin Cancer Res. 2018 24:6383-6395. PMID: 30190370

– Mao F, J Li, Q Luo, R Wang, Y Kong, C Carlock, Z Liu, Elzey BD, X Liu. Plk1 inhibition enhances the efficacy of BET epigenetic reader blockade in castration-resistant prostate cancer. Mol Cancer Ther 2018. 17:1554-1565. PMID: 29716963

– Lee HJ, Li J, Vickman RE, Li J, Liu R, Durkes A, Elzey BD, Yue S, Liu X, Ratliff TL, Cheng JX. Cholesterol Esterification Inhibition Suppresses Prostate Cancer Metastasis by Impairing the Wnt/β-catenin Pathway. Mol Cancer Res. 2018 16:974-985. PMID: 29545473

– Ozcelikkale A, Shin K, Noe-Kim V, Elzey BD, Dong Z, Zhang JT, Kim K, Kwon IC, Park K, Han B. Differential response to doxorubicin in breast cancer subtypes simulated by a microfluidic tumor model. J Control Release. 2017. Nov 28;266:129-139. PMID: 28939108

– Bhandari PN, Cui Y, Elzey BD, Goergen CJ, Long CM, Irudayaraj J. Oxygen nanobubbles revert hypoxia by methylation programming. Sci Rep. 2017. 7:9268. PMID: 28839175

– Orillion A, Hashimoto A, Damayanti N, Shen L, Adelaiye-Ogala R, Arisa S, Chintala S, Ordentlich P, Kao C, Elzey B, Gabrilovich D, Pili R. Entinostat Neutralizes Myeloid-Derived Suppressor Cells and Enhances the Antitumor Effect of PD-1 Inhibition in Murine Models of Lung and Renal Cell Carcinoma. Clin Cancer Res. 2017. 23:5187-5201. PMID: 28698201

– Lee J, Choi S, Kim KH, Heng HG, Torregrosa-Allen SE, Ramsey BS, Elzey BD, Won YY. Nontoxic Formulations of Scintillation Nanocrystals for Use as X-ray Computed Tomography Contrast Agents. Bioconjug Chem. 2017. 28:171-182. PMID: 27791362

– Deng X, Shao G, Zhang HT, Li C, Zhang D, Cheng L, Elzey BD, Pili R, Ratliff TL, Huang J, Hu CD. Protein arginine methyltransferase 5 functions as an epigenetic activator of the androgen receptor to promote prostate cancer cell growth. Oncogene. 2017. 36:1223-1231. PMID: 27546619

– Bi P, Yue F, Karki A, Castro B, Wirbisky SE, Wang C, Durkes A, Elzey BD, Andrisani OM, Bidwell CA, Freeman JL, Konieczny SF, Kuang S. 2016 Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med. 213:2019-37. PMID: 27573812

– Collins CJ, Mondjinou Y, Loren B, Torregrosa-Allen S, Simmons CJ, Elzey BD, Ayat N, Lu ZR, Thompson D. Influence of Molecular Structure on the In Vivo Performance of Flexible Rod Polyrotaxanes. Biomacromolecules 2016. 17:2777-86. PMID: 27387820.

– Sun, B, MS Taha, B Ramsey, S Torregrosa-Allen, BD Elzey, Y Yeo. Intraperitoneal chemotherapy of ovarian cancer by hydrogel depot of paclitaxel nanocrystals. J Control Release 2016. 235:91-98. PMID 27238443.

– Bozkus, CC, BD Elzey SA Crist, LG Ellies, and TL Ratliff. Expression of cationic amino acid transporter 2 is required for myeloid-derived suppressor cell-mediated control of T cell immunity. J Immunol 2015. 195:5237-50. PMID:26491198

– Crist, SA, BD Elzey, MT Ahmann, TL Ratliff. Early Growth Response-1 (Egr-1) and Nuclear Factor of Activated T cells (NFAT) cooperate to mediate CD40L expression in megakaryocytes and platelets. J Biol Chem 2013. 288:33985-96. PMID: 24106272

– Haverkamp, JM, SA Crist, BD Elzey, C Cimen, and TL Ratliff. In vivo suppressive function of myeloid-derived suppressor cells is limited to the inflammatory site. Eur. J. Immunol. 2011. 41:749-759. PMID: 21287554

– Elzey, BD, TL Ratliff, JM Sowa, and SA Crist. Platelet CD40L at the interface of adaptive immunity. Invited Review. Thrombosis Research. 2011. 127:180-183. PMID: 21075431

– Sowa, JM, SA Crist, TL Ratliff, and BD Elzey. Platelet influence of T and B cell responses. Invited Review. Arch Immunol et Ther. 2009. 57:235-241. PMID: 19578816

– Elzey, BD, NW Schmidt, SA Crist, TP Kresowik, JT Harty, B Nieswandt, and TL Ratliff. Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge. Blood. 2008. 111:3684-3691. PMID: 18256321

– Sprague DL, BD Elzey, SA Crist, TJ Waldschmidt, RJ Jensen, TL Ratliff. Platelet-mediated Modulation of Adaptive Immunity: Unique Delivery of CD154 Signal by Platelet-derived Membrane Vesicles. Blood. 2008. 111:5028-5036. PMID: 18198347

– Elzey BD, JF Grant, HW Sinn, B Nieswandt, TJ Waldschmidt, and TL Ratliff. Cooperation Between Platelet-derived CD154 and CD4+ T Cells for Enhanced Germinal Center Formation. J. Leuk. Biol. 2005. 78:80-84. PMID: 15899982

– SA Crist, BD Elzey, AT Ludwig, TS Griffith, JB Staack, SR Lentz and TL Ratliff. Expression of TNF-related Apoptosis-inducing Ligand (TRAIL) in Megakaryocytes and Platelets. Exp Hematol. 2004. 32:1073-81. PMID: 15539085

– Elzey BD, J Tian, RJ Jensen, AK Swanson, JR Lees, SR Lentz, CS Stein, B Nieswandt, Y Wang, BL Davidson, and TL Ratliff. Platelet-Mediated Modulation of Adaptive Immunity: A Communication Link Between Innate and Adaptive Immune Compartments. Immunity. 2003. 19:9-19. PMID: 12871635