William G. Van Alstine, DVM, PhD

Department of Comparative Pathobiology

Professor Emeritus

Purdue University College of Veterinary Medicine
625 Harrison Street
West Lafayette, IN 47907

Email: billvan@purdue.edu


1987 - PhD | Iowa State University
1984 - MS | Iowa State University
1981 - DVM | University of Missouri
1978 - BS | University of Missouri

Selected Publications

– Wei H, Lenz SD, Van Alstine WG, Stevenson GW, Langohr IM, Pogranichniy RM: Infection of cesarean-derived colostrum-deprived pigs with porcine circovirus type 2 and swine influenza virus (H1N1). Comparative Medicine 60(1), 45-50, 2010.

– Van Alstine WG, Mitsui I: Sudden death associated with hypertrophic cardiomyopathy in an Alpaca (Llama pacos). J Vet Diag Investigation 22(3): 448-450, 2010.

– Miguel JC, Van Alstine WG, Chen J, Johnson R: Expression of inflammatory cytokines and Toll-like receptors in the brain and respiratory tract of pigs infected with PRRS virus. Vet Immunology and Immunopathology 135: 314-319, 2010.

– Pavcnik D, Tekulve K, Van Alstine WG, Uchida BT, Pavcnik-Arnol M, Keller FS, Rosch J: Biodisk, A new device for closure of patent foramen ovale. A feasibility study in swine. J Catheterization and Cardiovascular Interventions 75:861-867, 2010.

– Xu P, Bajaj G, Shrugg T, Van Alstine WG, Yoon, Y: Zwitterionic chitosan derivatives for pH sensitive stealth coating. Biomacromolecules 11: 2352-2358, 2010.

– Raizman EA, Pogranichniy R, Levy M, Negron M, Van Alstine WG: Experimental infection of colostrum-deprived calves with bovine viral diarrhea virus type-1 isolated from free-ranging white-tailed deer. Can J Vet Research 57(1): 65-68, 2011.

– Dake MD, Van Alstine WG, Zhou Q, Ragheb AO: Polymer-free paclitaxel-coated Zilver PTX stents - evaluation of pharmacokinetics and comparative safety in porcine arteries. J Vasc Intervent Radiol 22(5): 603-610, 2011.

– Che TM, Johnson RW, Kelley KW, Van Alstine WG, Dawson KA, Moran CA, Pettigrew JE: Mannan oligosaccharide improves immune response and growth efficiency in nursery pigs experimentally infected with PRRS virus. JAS 89:2592-2602, 2011.

– Bahls M, Bidwell CA, Hu J, Granada JF, Krueger CG, Reed JD, Van Alstine WG, Newcomer SC: Gene expression differences in the brachial and femoral arteries of Rapacz hypercholesterolemic swine. Physiological Genomics 43: 781-788, 2011

– Che TM, Johnson RW, Kelley KW, Van Alstine WG, Dawson KA, Moran CA, Pettigrew JE: Mannan oligosaccharide modulates gene expression profile in pigs experimentally infected with porcine reproductive and respiratory syndrome virus. JAS 89:3016-3029, 2011.

– Bajaj G, Van Alstine WG, Yoon Y: Zwitterionic chitosan derivative, an new biocompatible pharmaceutical excipient prevents endotoxin-mediated cytokine release. PLoS ONE, PONE-S-11-20508. December, 2011.

– Johnson JK, Vemulapalli TH, Van Alstine WG, Roberts CS, Garner JP, Hickman DL: Retained fetal membranes in female C57BL/6NCrl mice: description of clinical case presentations and related epidemiological findings. Comparative Medicine 61(6): 505-509, 2011

– Negron M, Pogranichniy R, Hilton WM, Levy M, Van Alstine WG, Raizman EA,: Evaluation of horizontal transmission of BVD virus type 1a from experimentally infected white-tailed deer fawns (Odocoileus virginianus) to colostrum-deprived calves. Am J Vet Res 73(2):257-262, 2012

– Che TM, Johnson RW, Kelley KW, Van Alstine WG, Dawson KA, Moran CA, Pettigrew JE: Mannan oligosaccharide increases serum concentrations of antibodies and inflammatory mediators in weanling pigs experimentally infected with PRRS virus. JAS 90(8): 2784-93, 2012.

– Connolly S, Frank C, Thompson C, Van Alstine WG, Gelb H, Heng H, Klosterman E, KiupelM, Grooters AM: Dual infection with Pythium insidiosum and Blastomyces dermatitidis in a dog. Vet Clin Pathol 41(3):419-23, 2012

– Cole CD, Bell LN, Van Alstine WG, Alloosh M, Sturek M, Chalasnai N, Saxena R. High fat/cholesterol diet leads to accumulation of an EM-dense lamellar material in pig hepatocytes. Modern Pathology (25): supplement 2, p. 413, 2012.

– Pavcnik D, Tekulve K, Uchida BT, , Luo Z, Jeromet M, Van Alstine WG, Keller FS, Rosch J: Double Biodisk: A new bioprosthetic device for transcatheter closure of atrial septal defects - a feasibility study in adult sheep. Radiol Oncol 46(2):89-96, 2012.

– Giday S, Van Alstine WG, Van Vleet J, Ducharme R, Bradner E, Florea M, Negron-Garcia J, Ringenberger K: Safety Anallysis of a Hemostatic Powder (Hemospray) in a porcine model of severe gastric bleeding. Dig Dis Sci 58(12):3422-8, 2013.

– LiuY, Che TM, Song M, Lee JJ, Almeida JAS, Bravo D, Van Alstine WG, Pettigrew JE: Dietary plant extract improves immune responses and growth efficiency of pigs experimentally infected with PRRS virus. JAS 91(12):5668-79, 2013.

– Elmore M, Burton M, Conrad M, Rytych J, Van Alstine WG, Johnson R: Respiratory viral infection in neonatal piglets causes marked microglia activation in the hippocampus and deficits in spatial learning. J of Neurosciences, Accepted 2013.

– Bahls M, Bidwell AC, Hu J, Eollez A, Kaluza LG, Granada FJ, Krueger GC, Reed DJ, Laughlin HM, Van Alstine WG, Newcomer S: Gene expression differences during the heterogenous progression of peripheral atherosclerosis in familial hypercholesterolemic swine. BMC Genomics 14: 443+, 2013.

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