Center for Paralysis Research

Spinal Cord Injury

Spinal Cord Injury

Each year, about 13,000 new cases of traumatic spinal cord injuries occur in the U.S. alone. The biologic and functional consequences of such injuries are often permanent and the financial, emotional and social impacts far reaching. CPR seeks to understand the underlying pathophysiology of spinal cord damage and is also is engaged in translation research to repair, restore or regenerate damaged tissues through a variety of novel technologies.

Spinal Cord Injury Research: Overview
Brain Injury

Brain Injury

Traumatic brain injuries occur in many forms including stroke, acute head trauma, mild repetitive trauma (concussions). These modes of trauma can lead to neurodegeneration as well as functional and cognitive defects. The center is investigating novel polymer based fusogens and molecular scavengers that exert neuroprotective effects to reduce the impact of secondary injury in nervous tissues.

Brain Injury: Overview

Center for Paralysis Research:

The Center for Paralysis Research (CPR) is an interdisciplinary basic science and neuroengineering group located within Purdue University College of Veterinary Medicine. CPR has an unmatched record of moving basic research into clinical development, with three technologies having gone through FDA Phase 1 trials and one treatment already approved for multiple sclerosis patients. The center investigates innovative ways to solve problems of the nervous system and welcomes ideas that challenge traditional dogma. 


  • Seminar for Neurotrauma and Diseases continues for CPR
  • Recent graduates Seth Herr and Jonathan Tang passed their final defenses
  • Technology to treat neurological diseases, pain wins Indiana fund's commercialization award
  • Neuroscience seminar highlights brain injuries and neurodegenerative diseases
  • Dr. Riyi Shi named the Mari Hulman George Endowed Professor of Applied Neuroscience
  • Purdue innovators receive $1.3 million from Department of Defense for research on traumatic brain injury, Alzheimer's
  • Dr. Riyi Shi named new Director of Center for Paralysis Research

Recent Publications

  1. Herr, S., Malek, S., Rochat, M. C., Moore, G. E., Ko, J. C., Shi, R. (2021). Evidence of acrolein in synovial fluid of dogs with osteoarthritis as a potential inflammatory biomarker. BioMed Central. Accepted.
  2. Shen, X., Caglar Özen, A., Sunjar, A., Ilbey, S., Shi, R., Chiew, M., Emir, U. (2021). Myelin imaging using 3D dual-echo ultra-short echo time MRI with Rosette k-space pattern. BioRxiv
  3. Han, H. X., Fernandez, J. M., Swanberg, C., Shi, R., Bartlett, E. (2021). Longitudinal auditory pathophysiology following mild blast induced trauma. BioRxiv. Accepted. DOI:
  4. De Rus Jacquet, A., Ambaw, A., Tambe, M., Ma, S., Timmers, M.m Grace, M., Wu, Q., Simon, J., McGabe, G., Lila, M., Shi, R., Rochet, J. (2021). Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models. Food and Function. Accepted.
  5. Herr, S., Shi, L., Gianaris, T., Jiao, Y., Sun, S., Race, N., Shapiro, S., Shi, R. (2021). Critical role of mitochondrial aldehyde dehydrogenase 2 in acrolein sequestering in rat spinal cord injury. Neural Regeneration Research. Accepted.
  6. Eaton, M., Que, Z., Zhang, J., Beck, K., Shi, R., McDermott, J., Ladisch, M., Yang, Y. (2021). Multi-electrode array of sensory neurons as an in vitro platform to identify the nociceptive response to pharmaceutical buffer systems of injectable biologics. Pharmaceutical ResearchDOI: 10.1007/s11095-021-03075-z
  7. Race, N. S., Andrews, K. D., Lungwitz, E. A., Vega Alvarez, S. M., Warner, T. R., Acosta, G., Cao, J., Lu, K., Liu, Z., Dietrich, A. D., Majumdar, S., Shekar, A., Truitt, W. A., Shi, R. (2021).Psychosocial impairment following mild blast-induced traumatic brain injury in rats. Behavioral Brain Research.
  8. Shi, L., Lin, Y., Jiao, Y., Herr, S., Tang, J., Rogers, E., Chen, Z., Shi, R. (2021). Acrolein scavenger dimercaprol offers neuroprotection in an animal model of Parkinson's disease: Implication of acrolein and TRPA1. Translational Neurodegeneration, 10(13).
  9. Kish, B., Herr, S., Yang, H., Sun, S., Shi, R., Tong, Y. (2021). Whole body measurements using near-infrared spectroscopy in a rat spinal cord contusion injury model. The Journal of Spinal Cord Medicine. DOI: 10.1080/10790268.2021.1911504
  10. Uzunalli, G., Herr, S., Dieterly, A. M., Shi, R., Lyle, L. T. (2021). Structural disruption of the blood-brain barrier in repetitive primary blast injury. BioMed Central, 18(2).
  11. Ren, Z., Qi, Y., Sun, S., Tao, Y., Shi, R. (2020). Mesenchymal stem cell-derived exosomes: Hope for spinal cord injury repair. Stem Cells and Development, 29(23).
  12. Nguyen, T. N. H., Nolan, J. K., Cheng, X., Park, H., Wang, Y., Lam, S., Lee, H., Kim, S. J., Shi, R., Chubykin, A. A., Lee, H. (2020). Fabrication and ex vivo evaluation of activated carbon-Pt microparticle based glutamate biosensor. Journal of Electoanalytical Chemistry, 866.
  13. Shi, L., Huang, C., Luo, Q., Xia, Y., Liu, W., Zeng, W., Cheng, A., Shi, R., Zhengli, C. (2020). Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway. Aging, 12(10), 9515-9533.
  14. Latorre, A., Kwong, M. T., Garcie-Grajales, J. A., Shi, R., Jerusalem, A., Peña, J.(2019). Model calibration using a parallel differential evolution algorithm in computational neuroscience: Simulation of stretch induced nerve deficit. Journal of Computational Science, 39. 1016/j.jocs.2019.101053
  15. Chong, L., Tian, R., Shi, R., Ouyang, Z., Xia, Y. (2019). Coupling the Paternò-Büchi (PB) reaction with mass spectrometry to study unsaturated fatty acids in mouse model of multiple sclerosis. Frontiers in Chemistry, 7(807).
  16. Huang, C., Ma, W., Luo, Q., Shi, L., Xia, Y., Lao, C., Liu, W., Zou, Y., Cheng, A., Shi, R., Chen, Z. (2019). Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice. Aging, 11(21), 9846-9861.
  17. Nolan, J. K., Nguyen, T. N. H., Fattah, M., Page, J. C., Shi, R., Lee, H. (2019). Ex vivo electrochemical measurement of glutamate release during spinal cord injury. MethodsX, 6, 1894-1900.
  18. Shi, L., Huang, C., Luo, Q., Rogers, E., Xia, Y., Liu, W., Ma, W., Zeng, W., Gong, L., Fang, J., Tang, L., Cheng, A., Shi, R., Chen, Z. (2019) The association of iron and the pathologies of Parkinson’s Diseases in MPTP/MPP +- induced neuronal degeneration in non-human primates and in cell culture. Frontiers in Aging Neuroscience, 11(215).
  19. Vike, N., Tang, J., Talavage, T., Shi, R., Rispoli, J. (2019). Determination of acrolein-associated T1 and T2 relaxation times and noninvasive detection using nuclear magnetic resonance and magnetic resonance spectroscopy. Applied Magnetic Resonance, 50(11), 1291-1303. DOI: 1007/s00723-019-01148-2
  20. Acosta, G., Race, N., Herr, S., Fernandez, J., Tang, J., Rogers, E., Shi, R. (2019). Acrolein-mediated alpha-synuclein pathology involvement in the early post-injury pathogenesis of mild blast-induced Parkinsonian neurodegeneration. Molecular and Cellular Neuroscience, 98, 140-154. DOI: 1016/j.mcn.2019.06.004
  21. Nguyen, T. N. H., Nolan, J. K., Park, H., Lam, S., Fattah, M., Page, J. C., Joe, H., Jun, M. B. G., Lee, H., Kim, S. J., Shi, R., Lee, H. (2019). Facile fabrication of flexible glutamate biosensor using direct writing of platinum nanoparticle-based nanocomposite ink. Biosensors and Bioelectronics, 131, 257-266.
  22. Li J. (2019). Weak direct current (DC) electric fields as a therapy for spinal cord injuries: Review and advancement of the oscillating field stimulator (OFS). Neurosurgical Review, 42, 825-834. DOI: 1007/s10143-018-01068-y

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