Publications from the Zhang Research Group

1. Silic, M.R., Murata, S.H., Park, S.J., Zhang, G. (2021). Evolution of inwardly rectifying potassium channels and their gene expression in zebrafish embryos. Developmental Dynamics. https://doi.org/10.1002/dvdy.425
2. Han, H., Jiang, G.Z., Kurami, R., Silic, M.R., Owens, J.L., Hu, C.D., Mittal, S.K., Zhang, G. (2021). Loss of smarcad1a accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish. Genes, Chromosomes and Cancer. 60:743–761. https://doi.org/10.1002/gcc.22983
3. Silic, M.R, Maya M.B., Zhang, G. (2021). Phylogenetic and developmental analyses indicate complex functions of Calcium‐Activated Potassium Channels in zebrafish embryonic development. Developmental Dynamics. https://doi.org/10.1002/dvdy.329
4. Wang, Y., Hsu, A.Y., Walton, E.M., Park, S.J., Syahirah, R., Wang, T., Zhou, W., Ding, C., Lemke, A.P., Zhang, G., Tobin, D.M., Deng, Q. (2021). A robust and flexible CRISPR/Cas9 based system for neutrophil-specific gene inactivation in zebrafish. (2021). J Cell Sci. https://doi.org/10.1242/jcs.258574
5. Gampala, S., Zhang, G., Chang, C.H., Yang, J.Y. Activation of AMPK sensitizes medulloblastoma to Vismodegib and overcomes Vismodegib-resistance. (2021) FASEB BioAdvances. 3: 459–469 https://doi.org/10.1096/fba.2020-00032
6. Silic, M.R., Wu Q., Kim, B.H., Golling, G., Chen, K.H., Freitas, R., Chubykin, A.A., Mittal, S.K., and Zhang, G. (2020). Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish. Genetics. 215: 1067-1084. https://doi.org/10.1534/genetics.120.303390
7. Kim BH, Zhang, G. (2020). Generating Stable Knockout Zebrafish Lines by Deleting Large Chromosomal Fragments Using Multiple gRNAs. G3: Genes|Genomes|Genetics. g3.401035.2019. https://doi.org/10.1534/g3.119.401035
8. Mohammed I.S.; Utturkar, S.; Lee, M.; Yang, H.H.; Cui, Z.; Atallah Lanman, N.; Zhang, G.; Ramos Cardona, X.E.; Mittal, S.K.; Miller, M.A. (2020). Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer. Cancers. 12, 418. https://doi.org/10.3390/cancers12020418
9. Lezzerini, M., Penzo, M., O'Donohue, M.F., Marques Dos Santos Vieira, C., Saby, M., Elfrink, H.L., Diets, I.J., Hesse, A.M., Coute, Y., Gastou, M., Nin-Velez, A., Nikkels, P.G.J., Olson, A.N., Zonneveld-Huijssoon, E., Jongmans, M.C.J. Zhang, G., van Weeghel, M., Houtkooper, R.H., Wlodarski, M.W., Kuiper, R.P., Bierings, M.B., van der Werff Ten Bosch, J., Leblanc, T., Montanaro, L., Dinman, J.D., Da Costa, L., Gleizes, P.E., MacInnes, A.W. (2020). Ribosomal protein gene RPL9 variants can differentially impair ribosome function and cellular metabolism. Nucleic Acids Research. 48(2):770-787. https://doi.org/10.1093/nar/gkz1042
10. Gonçalves O., Freitas R., Ferreira P., Araújo M., Zhang G., Mazan S., Cohn M.J., Castro L.F.C., Wilson J.M. (2019) Molecular ontogeny of the stomach in the catshark Scyliorhinus canicula. Scientific reports. 2019; 9(1):586. https://doi.org/10.1038/s41598-018-36413-0
11. Silic M.R., Zhang G. (2018). Visualization of Cellular Electrical Activity in Zebrafish Early Embryos and Tumors. JOVE, 134: e57330. https://dx.doi.org/10.3791/57330
12. Kumari K., Silic M.R., Jones-Hall Y.L., Nin-Velez A., Yang J.Y., Mittal S.K., Zhang G. (2018). Identification of RECK as an evolutionarily conserved tumor suppressor gene for zebrafish malignant peripheral nerve sheath tumors. Oncotarget, 9:23494-23504. https://doi.org/10.18632/oncotarget.25236.
13. Huang S., Shen, Y.J. Pham D., Jiang L., Kaplan, M.H., Zhang, G., Sun J. (2017). IRF4 modulates CD8 T cell sensitivity to IL-2 family cytokines. ImmunoHorizons, 1: 92-100. DOI: https://doi.org/10.4049/immunohorizons.1700020.
14. Ahi,Y.S., Hassan, A.O., Vemula, S.V., Li, K., Wen Jiang, W., Zhang, G. and Mittal, S.K. (2017). Adenoviral E4 33K protein interacts with virus packaging components and may serve as the putative portal. Scientific Reports, 7: 7582. https://doi.org/10.1038/s41598-017-07997-w
15. Zhang, R., Huang, S.Y., Li, K., Li, Y.H., Hsu, W.H., Zhang, G., Chang, C.J., Yang, J.Y. (2017). Dual degradation signals destruct GLI1: AMPK inhibits GLI1 through β-TrCP-mediated proteasome degradation. Oncotarget. https://doi.org/10.18632/oncotarget.17769
16. Cui Z, Shen, Y.J., Chen K.H., Mittal, S.K., Yang, J.Y., and  Zhang, G. (2017). KANK1 inhibits cell growth by inducing apoptosis through regulating CXXC5 in human malignant peripheral nerve sheath tumors.  Scientific Reports 7: 40325. https://doi.org/10.1038/srep40325
17. Hensley, M. R., Chua, R. F., Leung, Y. F., Yang, J. Y., Zhang, G. (2016) Molecular Evolution of MDM1, a "Duplication-Resistant" Gene in Vertebrates. PLoS One 11, e0163229. https://doi.org/10.1371/journal.pone.0163229
18. Hensley, M.R., Cui, Z., Chua, R.F.M., Simpson, S., Shammas, N.L., Yang, J.-Y., Leung, Y.F., and Zhang, G. (2016). Evolutionary and developmental analysis reveals KANK genes were co-opted for vertebrate vascular development. Scientific Reports 6, 27816. https://doi.org/10.1038/srep27816
19. Tarazona, O.A., Slota, L.A., Lopez, D.H., Zhang, G. & Cohn, M.J. (2016) The genetic program for cartilage development has deep homology within Bilateria. Nature, 533: 86–89. https://doi.org/10.1038/nature17398
20. Li, Y.H., Luo, J., Mosley, Y.Y., Hedrick, V.E., Paul, L.N., Chang, J., Zhang, G., Wang, Y.K., Banko, M.R., Brunet, A., Kuang, S., Wu, J.L., Chang, C.J., Scott, M.P., Yang, J.Y. (2015). AMP-Activated Protein Kinase Directly Phosphorylates and Destabilizes Hedgehog Pathway Transcription Factor GLI1 in Medulloblastoma. Cell Reports 12, 599-609. https://doi.org/10.1016/j.celrep.2015.06.054
21. Zhang G., Yang J.Y, Cui Z.B. (2015) New Insight into Cancer Aneuploidy in Zebrafish. International Review of Cell and Molecular Biology, 314: 149-170. https://doi.org/10.1016/bs.ircmb.2014.09.001
22. Zhang G., Hoersch S., Amsterdam A., Whittaker C.A., Beert E., Catchen, J.M., Farrington, S., Postlethwait, J.H., Legius E., Hopkins, N., Lees, J.A. (2013) Comparative Oncogenomic Analysis of Copy Number Alterations in Human and Zebrafish Tumors Enables Cancer Driver Discovery. PLoS Genetics 9(8): e1003734. https://doi.org/10.1371/journal.pgen.1003734
23. Zhang G., Vemulapalli, T.H., Yang J.Y. (2013) Phylooncogenomics: Examining the cancer genome in the context of vertebrate evolution. Applied & Translational Genomics, 2: 48-54. https://doi.org/10.1016/j.atg.2013.06.002
24. Zhang G., Hoersch S., Amsterdam A., Whittaker C.A,. Lees J.A., Hopkins N. (2010). Highly aneuploid zebrafish malignant peripheral nerve sheath tumors have genetic alterations similar to human cancers. Proceedings of the National Academy of Sciences, 107: 16940–16945. https://doi.org/10.1073/pnas.1011548107
25. Zhang, G. (2009). An Evo-Devo view on the origin of the backbone: evolutionary development of the vertebrae. Integrative and Comparative Biology 49: 178-186. https://doi.org/10.1093/icb/icp061
26. Zhang, G. Eames, B.F. and Cohn, M.J. (2009).  Evolution of Vertebrate Cartilage Development.  Current Topics in Developmental Biology 86: 15-42. https://doi.org/10.1016/S0070-2153(09)01002-3
27. Zhang, G. and Cohn, M.J. (2008). Genome duplication and the origin of the vertebrate skeleton. Current Opinion in Genetics & Development, 18:387–393. https://doi.org/10.1016/j.gde.2008.07.009
28. Freitas, R., Zhang, G. and Cohn, M. J (2007).  Biphasic Hoxd Gene Expression in Shark Paired Fins Reveals an Ancient Origin of the Distal Limb Domain. PLoS ONE, 2: e754. https://doi.org/10.1371/journal.pone.0000754
29. Zhang, G. and Cohn, M.J. (2006). Hagfish and lancelet fibrillar collagens reveal that type II collagen-based cartilage evolved in stem vertebrates. Proceedings of the National Academy of Sciences, 103: 16829-33. https://doi.org/10.1073/pnas.0605630103
30. Freitas, R., Zhang, G., Cohn, M.J. (2006). Evidence that mechanisms of fin development evolved in the midline of early vertebrates. Nature. 2006 442: 1033-7. https://doi.org/10.1038/nature04984
31. Zhang, G., Miyamoto, M.M., Cohn, M.J. (2006). Lamprey type II collagen and Sox9 reveal an ancient origin of the vertebrate collagenous skeleton. Proceedings of the National Academy of Sciences, 103: 3180-5. https://doi.org/10.1073/pnas.0508313103
32. Freitas, R., Zhang, G., Albert, J.S., Evans, D.H., Cohn, M.J. (2006). Developmental origin of shark electrosensory organs. Evolution and Development . 8: 74-80. https://doi.org/10.1111/j.1525-142X.2006.05076.x
33. Zhang, G., Chen, Q., Qiu, C.P., Xia, M.Y. (2002). Sequence Analysis of rDNA-LSU Gene of Orientobilharzia turkestanicum from Mainland of China. Chinese Journal of Parasitology and Parasitic Diseases. 20: 86-9. (In Chinese)
34. Zhang, G., Qiu, C.P., Qiu, D.C., Xia, M.Y. (2002). Study on molecular phylogeny of Schistosoma sinensium based on mitochondrial genes. Chinese Journal of Parasitology and Parasitic Diseases. 20: 10-3. (In Chinese)
35. Zhang, G., Olivier, V., Qiu, C.P., Jourdane, J., Xia, M.Y.  (2001). Afrique or Asie, quelle est l'origine evolutive des schistosomes humains? C. R. Acad. Sci. Paris, Sciences de la vie/Life Sciences. 324: 1001-1010. (In French)
36. Zhang, G., Qiu, C.P., Xia, M.Y. (2001). Research Progress of Schistosoma sinensium. Chinese Journal of Zoonosis. 17: 92-97. (In Chinese)
37. Wang, C.R., Zhang, G., Wang, W.J., Xu, C.B., Yu, W.C., Qiu, J.H., Xu, L.M., Shen, B.G., Xia, M.Y. (2001) Scanning electron microscopic study of the integumental surface of adult Orientobilharzia cheni.  Chinese Journal of Zoonosis. 17(2): 59-63. (In Chinese)
38. Zhang, G., Qiu, D.C., Wang, C.R., Xia, M.Y. (2001). Scanning electron microscopy of the tegument of the adult Schistosoma sinensium and Orientobilharzia turkestanicum var. tuberculata and comparison with other schistosomes. Chinese Journal of Verterinary Parasitology. 3: 1-5. (In Chinese)
39. Zhang, G., Qiu, C.P., Qiu, D.C., Chang, Z.S., Qin, Z.H., Xia, M.Y. (2001). Study on molecular phylogeny of Schistosoma sinensium based on nuclear ribosomal DNA. Chinese Journal of Parasitology and Parasitic Diseases. 19: 201-204. (In Chinese)
40. Zhang, G., Xia, M.Y. (2000). Progress of the schistosome genomics. Foreign Medical Science, Parasitology. 27: 212-217. (In Chinese)